Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA

Organic & Biomolecular Chemistry
Robert D GiacomettiStephen Hanessian

Abstract

The design, synthesis and biophysical evaluation of two highly-constrained tricyclic analogues of locked nucleic acid (LNA), which restrict rotation around the C4'-C5'-exocyclic bond (torsion angle γ) and enhance hydrophobicity in the minor groove and along the major groove, are reported. A structural model that provides insights into the sugar-phosphate backbone conformations required for efficient hybridization to complementary nucleic acids is also presented.

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Citations

Jul 20, 2016·Journal of Medicinal Chemistry·W Brad Wan, Punit P Seth
Aug 6, 2019·Nucleosides, Nucleotides & Nucleic Acids·Juan C SalinasStephen Hanessian
Feb 6, 2021·Nucleic Acids Research·Guillermo VasquezPunit P Seth

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