PMID: 11906279Mar 22, 2002Paper

Design, synthesis, and evaluation of opioid analogues with non-peptidic beta-turn scaffold: enkephalin and endomorphin mimetics

Journal of Medicinal Chemistry
Masakatsu EguchiMichael Kahn

Abstract

We have identified a mu-selective opioid receptor agonist without a cationic amino group in the molecule from libraries of bicyclic beta-turn peptidomimetics. The biologically active conformation of the lead is proposed to mimic an endomorphin type III 4 --> 1 beta-turn conformation.

References

Apr 1, 1979·European Journal of Pharmacology·S R ChildersS H Synder
Apr 1, 1977·FEBS Letters·C Garbay-JaureguiberryR Oberlin
Dec 1, 1991·Biophysical Journal·B M PettittM Karplus
Sep 11, 1990·European Journal of Biochemistry·D PiconeP A Temussi
Jul 1, 1988·Trends in Neurosciences·A MansourS J Watson
Nov 18, 1986·Biochemistry·M Hassan, M Goodman
Feb 26, 2000·Journal of Medicinal Chemistry·P W SchillerR Hirschmann

❮ Previous
Next ❯

Citations

Jun 27, 2003·Current Opinion in Chemical Biology·Adam GolebiowskiDavid E Portlock
Jul 18, 2012·Accounts of Chemical Research·Landon R Whitby, Dale L Boger
Apr 15, 2011·Journal of Chemical Information and Modeling·Zhijun Wu, Victor J Hruby
May 26, 2011·Journal of the American Chemical Society·Landon R WhitbyDale L Boger
Mar 8, 2012·Journal of Medicinal Chemistry·Adriano MollicaVictor J Hruby
Sep 11, 2012·Journal of Medicinal Chemistry·Attila BoricsGéza Tóth
Sep 22, 2012·Journal of Medicinal Chemistry·Rossella De MarcoLuca Gentilucci
Apr 10, 2008·The FEBS Journal·Luca GentilucciAndrea Bedini
Jan 6, 2004·Medicinal Research Reviews·Masakatsu Eguchi
May 22, 2010·ChemMedChem·Attila KeresztesGéza Tóth
Feb 1, 2006·Organic & Biomolecular Chemistry·David BlombergJan Kihlberg
Sep 13, 2003·The Journal of Peptide Research : Official Journal of the American Peptide Society·B LeitgebG Tóth
Feb 6, 2010·Organic & Biomolecular Chemistry·Filippo SladojevichAndrea Trabocchi
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shailesh P DudhgaonkarMythily Srinivasan
Mar 20, 2014·Molecular Cancer Research : MCR·Omar N AkramGanesh V Raj
Nov 18, 2006·The Journal of Organic Chemistry·Bryan LiZhongli Zhang
Nov 11, 2003·Journal of Combinatorial Chemistry·Roland E Dolle
Jun 7, 2021·Bioorganic & Medicinal Chemistry Letters·Truong Thanh Tung, Thang Nguyen Quoc
Nov 20, 2003·Journal of the American Chemical Society·Dan YangYun-Dong Wu
Dec 14, 2004·Journal of Medicinal Chemistry·Stina SaittonKristina Luthman
Mar 11, 2006·The Journal of Organic Chemistry·Eric Enholm, Tammy Low
May 11, 2004·The Journal of Organic Chemistry·David BlombergJan Kihlberg
May 21, 2005·The Journal of Organic Chemistry·Juris Fotins, David B Smithrud

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.