Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones

European Journal of Medicinal Chemistry
Chia-Chung LeeHsu-Shan Huang

Abstract

A series of symmetrical disubstituded 1,8-diamidoanthraquinones were synthesized and evaluated for anti-proliferation, telomerase inhibitory by TRAP assay, and hTERT expression by SEAP assay. All of the compounds tested, except for compounds 3a and 3s were selected by the NCI screening system. In addition, compounds 4e and 4k exhibited inhibitory effects on telomerase activity. Taken together, our findings indicated that the analysis of cytotoxicity and telomerase inhibition might provide information applicable for further developing potential telomerase targeting strategy.

References

Jun 21, 1995·Journal of the National Cancer Institute·G B Morin

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Citations

Aug 14, 2012·Advances in Urology·Angela Lamarca, Jorge Barriuso
Jun 25, 2015·Carcinogenesis·Sabine A S LangieAndrew R Collins
Dec 3, 2014·European Journal of Medicinal Chemistry·Vivek AsatiSanjay K Bharti
Jul 31, 2019·Medicinal Research Reviews·Xing ChenXin-Hua Liu

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