journal cover

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Bioorganic & Medicinal Chemistry Letters

Jun 9, 2009

Dong-Jo ChangYoung-Ger Suh

Abstract

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis o...read more

Mentioned in this Paper

Drug Formulation Process
Mice, Inbred BALB C
Restasis
Structure-Activity Relationship
Cyclosporine
Analog
Inhibitory Concentration 50
Graft Rejection
Autoimmune Diseases
Inflammation
23
Paper Details
References
  • References12
  • Citations2
12
  • References12
  • Citations2
1

Similar Papers Found In These Feeds

Graft Rejection

Graft rejection occurs when the donor's grafted tissue is rejected by the recipient's immune system, destroying the transplanted tissue. Discover the latest research on graft rejection here.

Immunosuppression

Immunosuppression trends for solid organ transplantation have undergone a perceptible shift over the past decade. Discover the latest research on immunosuppression here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Therapy for Autoimmunity

Currently treatments for autoimmune diseases are anti-inflammatory and immunosuppressive, although recent advances in regulatory T cell therapy have shown promise as a potential therapeutic strategy. Discover the latest research on Therapies for Autoimmunity here.

© 2020 Meta ULC. All rights reserved

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Bioorganic & Medicinal Chemistry Letters

Jun 9, 2009

Dong-Jo ChangYoung-Ger Suh

PMID: 19502058

DOI: 10.1016/j.bmcl.2009.05.054

Abstract

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis o...read more

Mentioned in this Paper

Drug Formulation Process
Mice, Inbred BALB C
Restasis
Structure-Activity Relationship
Cyclosporine
Analog
Inhibitory Concentration 50
Graft Rejection
Autoimmune Diseases
Inflammation
23

Similar Papers Found In These Feeds

Graft Rejection

Graft rejection occurs when the donor's grafted tissue is rejected by the recipient's immune system, destroying the transplanted tissue. Discover the latest research on graft rejection here.

Immunosuppression

Immunosuppression trends for solid organ transplantation have undergone a perceptible shift over the past decade. Discover the latest research on immunosuppression here.

Related Papers

Paper Details
References
  • References12
  • Citations2
12
  • References12
  • Citations2
1
/papers/design-synthesis-and-identification-of-novel/19502058