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Design, synthesis and identification of novel colchicine-derived immunosuppressant

Bioorganic & Medicinal Chemistry Letters

Aug 1, 2009

Dong-Jo ChangYoung-Ger Suh

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Abstract

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis o...read more

Mentioned in this Paper

Mice, Inbred C57BL
Cyclosporine
Colchicine
Inhibitory Concentration 50
Inflammation
Analog
Drug Formulation Process
Colchicine, (R)-Isomer
Structure-Activity Relationship
Skin Transplantation
20
Paper Details
References
  • References12
  • Citations2
12

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Design, synthesis and identification of novel colchicine-derived immunosuppressant

Bioorganic & Medicinal Chemistry Letters

Aug 1, 2009

Dong-Jo ChangYoung-Ger Suh

PMID: 19502058

DOI: 10.1016/j.bmcl.2009.05.054

Abstract

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis o...read more

Mentioned in this Paper

Mice, Inbred C57BL
Cyclosporine
Colchicine
Inhibitory Concentration 50
Inflammation
20

Related Papers

Paper Details
References
  • References12
  • Citations2
12

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