PMID: 15348408Sep 7, 2004Paper

Design, synthesis and properties of polyurethane hydrogels for tissue engineering

Journal of Materials Science. Materials in Medicine
Paola PetriniMaria Cristina Tanzi

Abstract

Due to their similarity to natural soft tissues, water-swellable polymeric materials (hydrogels) are, in principle, ideal candidates for scaffolds/matrices in tissue engineering. Polyurethanes (PU), hydrophilic but water-insoluble, can be obtained by the incorporation of hydrophilic soft segments, e.g. poly(ethylene oxide) (PEO). These materials possess the favorable characteristics of the family of PUs as well as the ability to mimic soft tissues. In this work, new crosslinked PU-hydrogels were prepared in a one-step bulk polymerization process using an aliphatic diisocyanate, PEO, a low molecular weight diol, and a tri-functional crosslinking agent. A porous structure was also obtained by air-incorporation under mechanical stirring at a controlled high speed during the polymerization. Structural characteristics of the compact (PU-HyC) and the porous (PU-HyP) material were investigated. Molecular weight between cross-links, M(c), and crosslinking density, rho(x), were typical of a low crosslinking degree. A homogeneous distribution of non-interconnecting pores (phi100 microm) was observed in PU-HyP. Both materials showed a high water adsorption. The swelling behavior and weight loss in water was affected by porosity. For their...Continue Reading

Citations

Feb 16, 2018·SLAS Discovery·Brian F NiemeyerKambez H Benam
Mar 18, 2006·Journal of Biomaterials Applications·Yu-Feng ZhangJin Ke
Jun 15, 2011·Tissue Engineering. Part C, Methods·Sebastian KreitzStefan Jockenhoevel
Feb 21, 2013·Journal of Materials Science. Materials in Medicine·Tapan Kumar GiriDulal Krishna Tripathi
Nov 22, 2011·Biomedical Materials·Amine HarraneBenjamin Nottelet
May 23, 2019·Journal of Biomedical Materials Research. Part a·Kecen XiaoQiang Fu
Feb 14, 2007·Macromolecular Bioscience·Poonam BorgaonkarDaniel F Schmidt
Nov 10, 2015·Nuclear Medicine and Molecular Imaging·Jeong Il KwonHwan-Jeong Jeong
Jan 3, 2013·Advanced Healthcare Materials·Silvia M MihailaAli Khademhosseini
Nov 5, 2020·Chemical Reviews·Andreas SteineggerSergey M Borisov
Aug 29, 2021·Polymers·Zhuonan Yu, Kuo-Kang Liu

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Biological Macromolecules
Khalid Mahmood ZiaMuhammad Shafiq
Journal of Biomaterials Science. Polymer Edition
Bumsang Kim, Nicholas A Peppas
Journal of Biomaterials Science. Polymer Edition
J D Fromstein, K A Woodhouse
International Journal of Biological Macromolecules
Khalid Mahmood ZiaMirza Nadeem Ahmad
© 2021 Meta ULC. All rights reserved