Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

Bioorganic & Medicinal Chemistry Letters
A ClementeE Valente

Abstract

A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the beta-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme.

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Citations

Dec 4, 2003·Bioorganic & Medicinal Chemistry·Gianfranco CainelliArianna Quintavalla
Dec 7, 2002·Bioorganic & Medicinal Chemistry Letters·Takayoshi KinoshitaToshiji Tada
Jun 23, 2012·Journal of Medicinal Chemistry·Łukasz WiniarskiMarcin Sieńczyk
Jun 18, 2011·Medicinal Research Reviews·Susana D LucasRui Moreira
Jun 8, 2012·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Arlinda Bytyqi-DamoniOktay Arslan
Jul 3, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Babita AnejaMohammad Abid
Oct 25, 2016·International Journal of Molecular Sciences·Hayriye GençHasan Özdemir
Feb 13, 2008·Bioorganic & Medicinal Chemistry Letters·Namdev S VatmurgeMukund V Deshpande
Mar 8, 2014·Beilstein Journal of Organic Chemistry·Gijs KoopmanschapRomano Va Orru
Oct 27, 2005·The Journal of Pharmacology and Experimental Therapeutics·Isabella Dell'AicaSpiridione Garbisa
Nov 13, 2009·Journal of Medicinal Chemistry·Jalmira MulchandeRui Moreira
Jun 21, 2020·Mini Reviews in Medicinal Chemistry·Taíse H O LeiteMarcus Vinícius N de Souza
Dec 12, 2002·Chemical Reviews·James C PowersKaren Ellis James
May 11, 2004·The Journal of Organic Chemistry·Emília ValenteJim Iley
May 21, 2010·Bioorganic & Medicinal Chemistry Letters·Natarajan ArumugamNarayanasamy Mathivanan

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