Abstract
Inhibition of angiogenesis through inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2) has been applied in cancer therapy because of its important role in promoting cancer growth and metastasis. In the presented study, a series of benzimidazol-furan hybrids was designed and synthesized through facile synthetic pathways. Evaluation of the synthesized compounds for their in vitro cytotoxic activity against breast (MCF-7) and hepatocellular (HepG2) carcinoma cell lines was performed. Two of the synthesized conjugates, 10b and 15, showed potent antiproliferative properties against MCF-7 cell line (IC50 = 21.25, 21.35 μM, respectively) in comparison to tamoxifen (IC50 = 21.57 μM). Additionally, compounds 10a, 10b, 15 and 17 showed promising potency (IC50 = 25.95, 22.58, 26.94 and 31.06 μM, respectively) against liver carcinoma cell line HepG2 in contrast to cisplatin (IC50 = 31.16 μM). Moreover, in vitro evaluation of the synthesized compounds for their effect on the level of VEGFR-2 in MCF-7 cell line showed their potent inhibitory activity relative to control untreated cells. Four compounds 10a, 10b, 14 and 15 showed 92-96% reduction in VEGFR-2 level, compared with tamoxifen and sorafenib which showed inhibition ...Continue Reading
Citations
Jun 8, 2018·Medicinal Research Reviews·Yuanyuan ShanJie Zhang
Jan 13, 2018·Archiv der Pharmazie·Hanaa M RoaiahSally S El-Nakkady
Aug 30, 2019·Archiv der Pharmazie·Heba T Abdel-MohsenHoda I El Diwani
Jan 29, 2020·Archiv der Pharmazie·Heba T Abdel-MohsenHoda I El Diwani
Feb 12, 2020·Archiv der Pharmazie·Heba T Abdel-MohsenMamdouh M Ali
Feb 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Heba T Abdel-MohsenMathias O Senge
Sep 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abd El-Galil E AmrElsayed A Elsayed
Dec 6, 2017·Archiv der Pharmazie·Parameshwar RavulaJanivara Nanjunde Gowda Narendra Sharath Chandra
Jan 8, 2019·European Journal of Medicinal Chemistry·Yuanyuan ShanQinhua Chen
Nov 21, 2020·Bioorganic & Medicinal Chemistry·Khaled El-AdlIbrahim H Eissa
Dec 10, 2019·Bioorganic Chemistry·Hazem A MahdyIbrahim H Eissa
Mar 16, 2021·Bioorganic Chemistry·Nawaf A AlsaifHazem Elkady
Apr 27, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Asmaa E KassabRasha A Hassan
May 6, 2021·Archiv der Pharmazie·Nashwa M SalehKhaled El-Adl
Jun 16, 2021·Archiv der Pharmazie·Sarah H M KhairatHoda I El Diwani
Aug 4, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Mohammed M AlanaziAlaa Elwan
Sep 4, 2021·Bioorganic & Medicinal Chemistry·Nawaf A AlsaifHazem A Mahdy