Designable Immune Therapeutical Vaccine System Based on DNA Supramolecular Hydrogels

ACS Applied Materials & Interfaces
Yu ShaoYan-Mei Li

Abstract

Immunotherapy is believed to be an ideal method to treat cancer because it can break the immunotolerance of tumor and induce robust immunoresponse. However, constructing a wide antigen-adaptive, easy-handling, and biodegradable system that can recruit and activate antigen-presenting cells (APCs) much effectively is still a challenge. Herein, we show an injectable DNA supramolecular hydrogel vaccine (DSHV) system which could efficiently recruit and activate APCs in vitro and in vivo. The in vitro processes have been visualized by fluorescence microscopy. Through intraperitoneal or subcutaneous injection, the DSHV system can mimic the function of a lymph node where the APCs are recruited and activated by the high local concentration of cytosine-phosphate-guanine. Subsequently, strong immune response and obvious antitumor effects have been obtained. Our findings demonstrated that the DSHV system could serve as a general platform for tumor vaccination and benefit the personalized cancer therapy in the near future.

References

Aug 30, 2000·Nature·A Aderem, R J Ulevitch
Mar 4, 2003·Nature Medicine·Thomas A Waldmann
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Markus Y Mapara, Megan Sykes
Jun 10, 2006·Nature Reviews. Drug Discovery·Arthur M Krieg
Apr 27, 2007·Nature·Danica P Galonić, David Y Gin
Sep 4, 2007·Nature Chemical Biology·Sampat IngaleGeert-Jan Boons
Jan 13, 2009·Nature Materials·Omar A AliDavid J Mooney
Oct 7, 2009·Expert Review of Vaccines·Jianglong ZhuSamuel J Danishefsky
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jai S RudraJoel H Collier
Feb 18, 2010·Nature Chemistry·Thomas J BoltjeGeert-Jan Boons
Mar 13, 2010·Annual Review of Biochemistry·Nadrian C Seeman
Dec 25, 2010·Advanced Materials·Yongzheng XingDongsheng Liu
Jun 29, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ankur SinghKrishnendu Roy
Aug 2, 2011·Nature Reviews. Drug Discovery·W Joost LesterhuisCornelis J A Punt
Aug 23, 2011·Chemical Society Reviews·Minseok Kwak, Andreas Herrmann
Dec 24, 2011·Nature·Ira MellmanGlenn Dranoff
May 17, 2012·Journal of the American Chemical Society·Zhi-Hua HuangYan-Mei Li
Feb 27, 2013·Chemical Society Reviews·Nikola GaidzikHorst Kunz
Apr 10, 2013·Current Opinion in Biotechnology·Veikko Linko, Hendrik Dietz
Jul 10, 2013·Advanced Materials·Juan JinDongsheng Liu
Feb 18, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Makiya NishikawaYoshinobu Takakura
Jul 9, 2014·Nature Reviews. Clinical Oncology·Ignacio MeleroHåkan Mellstedt
Aug 27, 2014·Advanced Materials·Ankur Singh, Nicholas A Peppas
Dec 20, 2014·Cancer Research·Amani Makkouk, George J Weiner
Feb 11, 2015·Accounts of Chemical Research·Samuel J DanishefskyChi-Huey Wong
Feb 20, 2015·Nature Communications·Eric A AppelRobert Langer
Oct 1, 2015·Annual Review of Biomedical Engineering·Nathan A HotalingJulia E Babensee
May 25, 2016·Chemical Communications : Chem Comm·Z Y SunY M Li
Feb 12, 2017·Accounts of Chemical Research·Dong WangDan Luo
Mar 2, 2017·Accounts of Chemical Research·Jason S KahnItamar Willner
Mar 17, 2017·Accounts of Chemical Research·Yu ShaoDongsheng Liu
Feb 1, 2016·Chemical Science·Mariusz Skwarczynski, Istvan Toth

❮ Previous
Next ❯

Citations

Nov 13, 2018·Advanced Materials·Thanh Loc NguyenJaeyun Kim
Jan 15, 2019·Biomaterials Science·Kewen Lei, Li Tang
Aug 6, 2019·Advanced Materials·Fengyun LiWeiwei Guo
Mar 9, 2020·Topics in Current Chemistry·Jie ChenLihua Wang
Aug 28, 2020·Frontiers in Chemistry·Hong-Guo Hu, Yan-Mei Li
Mar 4, 2020·Acta Pharmacologica Sinica·Fan YangZhi-Yong Qian
Oct 6, 2020·Frontiers in Pharmacology·Enrico LattuadaPatrizia Filetici
Dec 18, 2020·Chemical Communications : Chem Comm·Jun-Jun WuYan-Mei Li
Jun 23, 2020·Colloids and Surfaces. B, Biointerfaces·Diksha GuptaJitender Madan
Jul 28, 2020·Advanced Drug Delivery Reviews·Fangli MoWeihong Tan
Jul 7, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi ZhouJianqing Gao
May 4, 2021·Chemical Reviews·Santiago CorreaEric A Appel
Sep 12, 2020·Chemical Reviews·Wen-Hao Li, Yan-Mei Li
Oct 12, 2021·ACS Applied Materials & Interfaces·Bo YangDongsheng Liu
Sep 22, 2021·Angewandte Chemie·Dong WangDan Luo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.