Designed multiple ligands. An emerging drug discovery paradigm

doi:10.1021/jm058225d

PMID: 16220969DOI: 10.1021/jm058225dOct 14, 2005

Designed multiple ligands. An emerging drug discovery paradigm

Journal of Medicinal Chemistry

Richard Morphy, Zoran Rankovic

Abstract

No abstract listed.

Citations

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Jan 20, 2009·Brain Research Reviews·Praveen AnandAndrea G Hohmann

Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity

Feb 4, 2009·Journal of Inorganic Biochemistry·Marisol VieitesDinorah Gambino

Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity

Dec 5, 2008·Bioorganic & Medicinal Chemistry Letters·Chitalu C MusondaMarcel Kaiser

From ion channels to complex networks: magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy

Dec 3, 2008·Medical Hypotheses·Matt T BianchiSydney S Cash

Design of vanadium mixed-ligand complexes as potential anti-protozoa agents

Dec 19, 2008·Journal of Inorganic Biochemistry·Julio BenítezDinorah Gambino

Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC)

Nov 26, 2008·Bioorganic & Medicinal Chemistry Letters·Camilla P HansenBente Frølund

Synthesis and evaluation of 3-hydroxy-3-phenylpropanoate ester–AZT conjugates as potential dual-action HIV-1 Integrase and Reverse Transcriptase inhibitors

Jan 19, 2016·Bioorganic & Medicinal Chemistry·Meloddy H ManyerukePerry T Kaye

HDAC inhibitors in leukemia: current status and perspectives

Sep 2, 2008·Leukemia Research·Gregory Kouraklis

Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments

Dec 15, 2015·ChemMedChem·Giovanni BottegoniAndrea Cavalli

New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties

Jul 22, 2008·Bioorganic & Medicinal Chemistry·Rafael LeónMercedes Villarroya

Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A2A adenosine receptor homodimer

Jul 22, 2008·Bioorganic & Medicinal Chemistry Letters·Andrei A Ivanov, Kenneth A Jacobson

Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties

Mar 25, 2008·Bioorganic & Medicinal Chemistry·Clara CenaAlberto Gasco

Designing transient binding drugs: a new concept for drug discovery

May 13, 2008·Drug Discovery Today·Sten Ohlson

CoMFA analysis of dual/multiple PPAR activators

Mar 7, 2008·European Journal of Medicinal Chemistry·Palak ShahPrasad V Bharatam

Synthesis of pyrimidine and quinolone conjugates as a scaffold for dual inhibitors of HIV reverse transcriptase and integrase

Jan 30, 2008·Bioorganic & Medicinal Chemistry Letters·Zhengqiang Wang, Robert Vince

Neuroprotection in mice by NGP1-01 after transient focal brain ischemia

Feb 1, 2008·Brain Research·Jiukuan HaoUlrich Bickel

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

Nov 14, 2007·Bioorganic & Medicinal Chemistry Letters·Lorna PiazziAngela Rampa

A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic

Sep 14, 2007·Bioorganic & Medicinal Chemistry·Severo SalvadoriGianfranco Balboni

Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance

Mar 13, 2016·Neuropharmacology·Zi-Long WangRui Wang

New pentasubstituted pyrrole hybrid atorvastatin-quinoline derivatives with antiplasmodial activity

Mar 19, 2016·Bioorganic & Medicinal Chemistry Letters·Rita C C CarvalhoNubia Boechat

Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore

Mar 7, 2007·Bioorganic & Medicinal Chemistry·Gianfranco BalboniSevero Salvadori

Syntheses and anti-cancer activities of 2-[1-(indol-3-yl-/pyrimidin-5-yl-/pyridine-2-yl-/quinolin-2-yl)-but-3-enylamino]-2-phenyl-ethanols

Feb 6, 2007·Bioorganic & Medicinal Chemistry·Palwinder SinghSubodh Kumar

Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors

Feb 9, 2007·Bioorganic & Medicinal Chemistry·Jie ZhangGuanhua Du

Design and synthesis of 3,5-disubstituted benzamide analogues of DNK333 as dual NK1/NK2 receptor probes

Dec 16, 2006·Bioorganic & Medicinal Chemistry Letters·Venkat Manoj SwarnaVijaya L Korlipara

Fragments, network biology and designing multiple ligands

Feb 6, 2007·Drug Discovery Today·Richard Morphy, Zoran Rankovic

Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy type 1

Oct 17, 2015·Journal of the American Chemical Society·Lien NguyenSteven C Zimmerman

Review structure- and dynamics-based computational design of anticancer drugs

Sep 20, 2015·Biopolymers·Jung-Hsin Lin

Anti-Plasmodium falciparum activity of quinoline-sulfonamide hybrids

Jul 21, 2015·Bioorganic & Medicinal Chemistry·Luiz C S PinheiroAntoniana U Krettli

Multifunctional drugs with different CNS targets for neuropsychiatric disorders

Oct 24, 2006·Journal of Neurochemistry·Cornelis J Van der SchyfMoussa B H Youdim

Method for comparing the structures of protein ligand-binding sites and application for predicting protein-drug interactions

Jan 25, 2008·Proteins·Ryoichi MinaiHiroshi Hirota

How many traditional Chinese medicine components have been recognized by modern Western medicine? A chemoinformatic analysis and implications for finding multicomponent drugs

Nov 21, 2007·ChemMedChem·De-Xin KongHong-Yu Zhang

Peptides and pseudopeptides incorporating D-Phe-Pro-Arg and Arg-Gly-Asp lead sequences as potential antithrombotic agents

Apr 3, 2008·Journal of Peptide Science : an Official Publication of the European Peptide Society·Janez IlašDanijel Kikelj

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

May 5, 2007·ChemMedChem·Andreas BenderJeremy L Jenkins

Synthesis of 1,2-disubstituted benzimidazoles by a Cu-catalyzed cascade aryl amination/condensation process

Mar 10, 2007·Angewandte Chemie·Benli ZouDawei Ma

The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1

Feb 20, 2009·British Journal of Pharmacology·C J FowlerV Onnis

Hybrid lipoic acid derivatives to attack prion disease on multiple fronts

Mar 18, 2011·ChemMedChem·Salvatore BongarzoneMaria L Bolognesi

Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors

Aug 7, 2012·ChemMedChem·Massimo BertinariaG Enrico Rovati

Dual-acting diether derivatives of piperidine and homopiperidine with histamine H(3) receptor antagonistic and anticholinesterase activity

May 3, 2012·Archiv der Pharmazie·Marek BajdaBarbara Malawska

Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection

Jun 22, 2011·ChemMedChem·Jhih-Bin ChenJim-Min Fang

Bifunctional μ/δ opioid peptides: variation of the type and length of the linker connecting the two components

Nov 11, 2011·Chemical Biology & Drug Design·Jinguo DingPeter W Schiller

Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents

Jul 15, 2011·Chemical Biology & Drug Design·Mingyan YuXinyong Liu

Bicyclic derivatives of the potent dual aromatase-steroid sulfatase inhibitor 2-bromo-4-{[(4-cyanophenyl)(4h-1,2,4-triazol-4-yl)amino]methyl}phenylsulfamate: synthesis, SAR, crystal structure, and in vitro and in vivo activities

Jul 16, 2010·ChemMedChem·Paul M WoodBarry V L Potter

Protoporphyrin IX/Cobyrinate Derived Hybrids - Novel Activators of Soluble Guanylyl Cyclase

Mar 23, 2013·European Journal of Organic Chemistry·Mikołaj ChromińskiDorota Gryko

VinaMPI: facilitating multiple receptor high-throughput virtual docking on high-performance computers

Jul 3, 2013·Journal of Computational Chemistry·Sally R EllingsonJerome Baudry

HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and implications for drug design

Apr 28, 2011·Medicinal Research Reviews·Peng ZhanXinyong Liu

Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders

Apr 14, 2016·Schizophrenia Research and Treatment·Hyeong-Min Lee, Yuna Kim

Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities

Jul 21, 2010·ChemMedChem·Donatella BoschiAlberto Gasco

Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates

May 25, 2011·ChemMedChem·Paul M WoodBarry V L Potter

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

Jul 15, 2015·ACS Chemical Neuroscience·Federica PratiMaria L Bolognesi

A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design

May 30, 2013·British Journal of Pharmacology·A J KooistraC de Graaf

Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Mar 16, 2013·ChemMedChem·L W Lawrence WooBarry V L Potter

Fragment informatics and computational fragment-based drug design: an overview and update

Mar 21, 2012·Medicinal Research Reviews·Chunquan Sheng, Wannian Zhang

Application of GQSAR for Scaffold Hopping and Lead Optimization in Multitarget Inhibitors

Jul 1, 2012·Molecular Informatics·Subhash Ajmani, Sudhir A Kulkarni

Synthesis and pharmacological evaluation of novel 1'-[2-(difluoromethoxy)benzyl]-2'H,5'H-spiro[8-azabicyclo[3.2.1]octane-3,4'-imidazolidine]-2',5'-diones and their derivatives

Jan 22, 2014·Archiv der Pharmazie·Malavalli MadaiahBantal Veeresh

Xanthones from Swertia mussotii as multitarget-directed antidiabetic agents

Feb 1, 2014·ChemMedChem·Huan-Huan ZhengYu-Lin Li

Extensions to In Silico Bioactivity Predictions Using Pathway Annotations and Differential Pharmacology Analysis: Application to Xenopus laevis Phenotypic Readouts

Dec 1, 2013·Molecular Informatics·Sonia LiggiAndreas Bender

Synthesis and evaluation as antitumor agents of 1,4-naphthohydroquinone derivatives conjugated with amino acids and purines

Oct 15, 2013·Archiv der Pharmazie·Aurora MolinariArturo San Feliciano

Inhibitors of the arachidonic acid cascade: interfering with multiple pathways

Sep 11, 2013·Basic & Clinical Pharmacology & Toxicology·Karin MeirerEwgenij Proschak

Biological networks and drug discovery--where do we stand?

Aug 28, 2014·Drug Development Research·Tim Geppert, Herbert Koeppen

Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design

Mar 15, 2011·Drug Development Research·Francis W Muregi, Akira Ishih

Design, synthesis, and biological evaluation of 1,3-diarylpropenones as dual inhibitors of HIV-1 reverse transcriptase

May 23, 2014·ChemMedChem·Rita MeledduEnzo Tramontano

Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities

Nov 3, 2015·Journal of Medicinal Chemistry·Aubrie A HarlandHenry I Mosberg

Methods for mining HTS data

Jul 19, 2006·Drug Discovery Today·Gavin Harper, Stephen D Pickett

Screening the receptorome: an efficient approach for drug discovery and target validation

Jul 19, 2006·Drug Discovery Today·Ryan T StrachanBryan L Roth

Multipotent antioxidants: from screening to design

Jul 19, 2006·Drug Discovery Today·Hong-Yu ZhangGuang-Yan Tang

I want a new drug: G-protein-coupled receptors in drug development

May 23, 2006·Drug Discovery Today·Sabine Schlyer, Richard Horuk

The Bifunctional μ Opioid Agonist/Antioxidant [Dmt(1)]DALDA Is a Superior Analgesic in an Animal Model of Complex Regional Pain Syndrome-Type I

Sep 10, 2015·ACS Chemical Neuroscience·Peter W SchillerTerence J Coderre

Photochemical synthesis and anticancer activity of barbituric acid, thiobarbituric acid, thiosemicarbazide, and isoniazid linked to 2-phenyl indole derivatives

Apr 28, 2016·Journal of Chemical Biology·S Vijaya LaxmiAsha Jyothi Rao

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

Apr 6, 2016·European Journal of Medicinal Chemistry·Jean-Pierre JourdanPatrick Dallemagne

Low molecular weight dual inhibitors of factor Xa and fibrinogen binding to GPIIb/IIIa with highly overlapped pharmacophores

May 7, 2013·European Journal of Medicinal Chemistry·Uroš TrstenjakDanijel Kikelj

Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

Sep 5, 2015·Nature Reviews. Drug Discovery·Carmel B NanthakumarSimon J F Macdonald

New approaches in the design and development of cannabinoid receptor ligands: multifunctional and bivalent compounds

Mar 31, 2015·ChemMedChem·Martin Nimczick, Michael Decker

Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore

Jun 3, 2015·Archiv der Pharmazie·Natalia SzałajBarbara Malawska

Synthesis and Anticonvulsant Activity of Substituted-1,3-diazaspiro[4.5]decan-4-ones

Jun 3, 2015·Archiv der Pharmazie·Mohamed Nabil Aboul-EneinRasha Mohamed Hassan

New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease

Sep 14, 2015·European Journal of Medicinal Chemistry·Xiao-Ting LuoZhen-Guang Huang

Diverse ways of perturbing the human arachidonic acid metabolic network to control inflammation

Aug 4, 2015·Accounts of Chemical Research·Hu MengLuhua Lai

Chloroquine-based hybrid molecules as promising novel chemotherapeutic agents

May 12, 2015·European Journal of Pharmacology·Vandana Srivastava, Hoyun Lee

Dual-acting histone deacetylase-topoisomerase I inhibitors

Apr 30, 2013·Bioorganic & Medicinal Chemistry Letters·William GuerrantAdegboyega K Oyelere

Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents

Mar 7, 2013·Bioorganic & Medicinal Chemistry·Eugene M H YeeNaresh Kumar

(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase

Mar 3, 2015·European Journal of Medicinal Chemistry·Rita MeledduElias Maccioni

Design, synthesis and evaluation of 6-aryl-indenoisoquinolone derivatives dual targeting ERα and VEGFR-2 as anti-breast cancer agents

May 14, 2016·European Journal of Medicinal Chemistry·Zhichao TangHua Xiang

Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases

May 27, 2014·European Journal of Medicinal Chemistry·Gema C González-MuñozMaría Isabel Rodríguez-Franco

Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity

Jun 29, 2010·Bioorganic & Medicinal Chemistry·Sérgio M MarquesM Amélia Santos

Molecular modeling and UV-vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ)

Nov 26, 2010·Bioorganic & Medicinal Chemistry Letters·Vanessa A OteloCarla M S Menezes

Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain

Apr 2, 2016·Journal of Medicinal Chemistry·Karel GuillemynSteven Ballet

Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics

Apr 16, 2016·Future Medicinal Chemistry·Michela RosiniAnna Minarini

Creation of a free, Internet-accessible database: the Multiple Target Ligand Database

Apr 22, 2015·Journal of Cheminformatics·Chao ChenJinming Zhou

Molecular perception of interactions between bis(7)tacrine and cystamine-tacrine dimer with cholinesterases as the promising proposed agents for the treatment of Alzheimer's disease

Jun 6, 2015·Journal of Biomolecular Structure & Dynamics·Mahboobeh EslamiSeyed Abolfazl Seyed Sajadi

Dual Inhibitors Against Topoisomerases and Histone Deacetylases

Jul 8, 2015·Journal of Cancer Prevention·Young Ho Seo

Insights into the Modulation of Dopamine Transporter Function by Amphetamine, Orphenadrine, and Cocaine Binding

Jun 25, 2015·Frontiers in Neurology·Mary Hongying ChengIvet Bahar

A ranking method for the concurrent learning of compounds with various activity profiles

Feb 3, 2015·Journal of Cheminformatics·Alexander DörrAndreas Zell

Synthesis, antioxidant and cytoprotective evaluation of potential antiatherogenic phenolic hydrazones. A structure-activity relationship insight

Jun 14, 2014·Bioorganic & Medicinal Chemistry·Corinne Vanucci-BacquéMichel Baltas

Platinum(II) metal complexes as potential anti-Trypanosoma cruzi agents

Jan 30, 2008·Journal of Inorganic Biochemistry·Marisol VieitesDinorah Gambino

Why should we use multifunctional neuroprotective and neurorestorative drugs for Parkinson's disease?

Nov 19, 2008·Parkinsonism & Related Disorders·Moussa B H YoudimCornelis J Van der Schyf

Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistry

Dec 17, 2011·Bioorganic & Medicinal Chemistry Letters·Pardeep SinghKrishna Bisetty

Identification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: the special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazole

Feb 7, 2013·Bioorganic & Medicinal Chemistry Letters·Andrei A GakhErnest Hamel

Synthesis and evaluation of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors

Feb 19, 2013·Bioorganic & Medicinal Chemistry·Temitope O OlomolaPerry T Kaye

Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives

Apr 15, 2015·Bioorganic & Medicinal Chemistry·Krzysztof KamińskiBarbara Filipek

Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors

Apr 11, 2014·Bioorganic & Medicinal Chemistry Letters·Olivér ÉliásIstván Gyertyán

Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites

Jun 27, 2006·Bioorganic & Medicinal Chemistry·Christophe DardonvilleLuis F Callado

Cyclic nucleotide-based therapeutics for chronic obstructive pulmonary disease

May 9, 2014·Current Opinion in Pharmacology·Mark A Giembycz, Donald H Maurice

Novel hybrid selenosulfonamides as potent antileishmanial agents

Jan 23, 2014·European Journal of Medicinal Chemistry·Ylenia BaquedanoCarmen Sanmartín

Dual anticoagulant/antiplatelet persulfated small molecules

Apr 1, 2011·European Journal of Medicinal Chemistry·Marta Correia-da-SilvaMadalena M M Pinto

The emergence of designed multiple ligands for neurodegenerative disorders

May 4, 2011·Progress in Neurobiology·Werner J GeldenhuysCornelis J Van der Schyf

Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents

May 30, 2014·European Journal of Medicinal Chemistry·Koneni V SashidharaGitika Bhatia

Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain

Oct 3, 2013·Life Sciences·Alexander T PodolskyTodd W Vanderah

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD

Jan 19, 2015·Bioorganic & Medicinal Chemistry Letters·Maria DigiacomoSimona Rapposelli

Multi-target approach for natural products in inflammation

Aug 31, 2014·Drug Discovery Today·Andreas Koeberle, Oliver Werz

Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease

Jan 28, 2015·Bioorganic & Medicinal Chemistry·Poonam MeenaManisha Tiwari

Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents

Feb 25, 2015·Bioorganic & Medicinal Chemistry·Natalia GuziorBarbara Malawska

Differential inhibition of signaling pathways by two new imidazo-pyrazoles molecules in fMLF-OMe- and IL8-stimulated human neutrophil

Aug 28, 2013·European Journal of Pharmacology·Rita SelvaticiSusanna Spisani

Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs

Feb 24, 2015·Bioorganic & Medicinal Chemistry· Mehr-un-NisaVictor J Hruby

Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin

Jan 31, 2015·Organic & Biomolecular Chemistry·O GherbovetF Roussi

Pd-catalyzed coupling reaction of fluorinated propargyl amidines with aryl iodides

Nov 3, 2012·Organic & Biomolecular Chemistry·Shan LiYongming Wu

New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents

Dec 6, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Bruno DemoroDinorah Gambino

Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties

Jan 27, 2015·European Journal of Medicinal Chemistry·Natalia GuziorBarbara Malawska

Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia

Jan 6, 2015·European Journal of Medicinal Chemistry·Marcin KołaczkowskiPrzemysław Bienkowski

Design and Synthesis of Novel Hybrid Molecules against Malaria

Mar 4, 2015·International Journal of Medicinal Chemistry·Melanie Lödige, Luisa Hiersch

Why do we need multifunctional neuroprotective and neurorestorative drugs for Parkinson's and Alzheimer's diseases as disease modifying agents

Jun 1, 2010·Experimental Neurobiology·Moussa B H Youdim

An expedient synthesis, acetylcholinesterase inhibitory activity, and molecular modeling study of highly functionalized hexahydro-1,6-naphthyridines

Feb 25, 2015·BioMed Research International·Abdulrahman I AlmansourMohamed Ashraf Ali

Predicting targets of compounds against neurological diseases using cheminformatic methodology

Nov 27, 2014·Journal of Computer-aided Molecular Design·Katarina NikolicJohn B O Mitchell

Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I

Apr 30, 2013·Bioorganic & Medicinal Chemistry Letters·Nurulain T ZaveriLawrence Toll

BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice

Mar 29, 2016·British Journal of Pharmacology·Ning LiRui Wang

Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands

May 6, 2016·Journal of Medicinal Chemistry·Aubrie A HarlandHenry I Mosberg

Polypharmacology of dopamine receptor ligands

May 29, 2016·Progress in Neurobiology·S ButiniH Stark

Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1

Jun 16, 2016·Bioorganic & Medicinal Chemistry Letters·Yunxin CaiPeter W Schiller

Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies

Jul 5, 2016·Frontiers in Neuroscience·Katarina NikolicJohn B O Mitchell

Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease

Jul 8, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Fan LiXiao-Bing Wang

How many drugs are catecholics

Sep 14, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Da-Peng YangHong-Yu Zhang

Discovery of novel anti-HIV agents via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry-based approach

Jul 12, 2016·Expert Opinion on Drug Discovery·Ping GaoXinyong Liu

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile(9)]PK20 in an acute pain treatment in rodents

Jul 31, 2016·Brain Research·Patrycja KleczkowskaAndrzej W Lipkowski

Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands

Aug 9, 2016·Bioorganic & Medicinal Chemistry Letters·Olivér ÉliásIstván Greiner

Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics

Aug 4, 2016·European Journal of Medicinal Chemistry·Xiao-Wen ChenJian-Qi Li

Computational approaches for innovative antiepileptic drug discovery

Jul 28, 2016·Expert Opinion on Drug Discovery·Alan Talevi

Multi-target therapeutics for neuropsychiatric and neurodegenerative disorders

Aug 11, 2016·Drug Discovery Today·Priya BawaViness Pillay

Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation

Aug 26, 2016·European Journal of Medicinal Chemistry·Anna WięckowskaBarbara Malawska

Discovery of novel xanthine compounds targeting DPP-IV and GPR119 as anti-diabetic agents

Aug 26, 2016·European Journal of Medicinal Chemistry·Gang LiHaihong Huang

Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex

Nov 4, 2015·Acta Crystallographica. Section D, Biological Crystallography·Ghader BashiriEdward N Baker

Synthesis and Antileukemic Activities of Piperlongumine and HDAC Inhibitor Hybrids against Acute Myeloid Leukemia Cells

Aug 10, 2016·Journal of Medicinal Chemistry·Yi LiaoZhihui Qin

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines

Aug 20, 2016·Journal of Medicinal Chemistry·Eugene Guorong YangBrian W Dymock

OCEAN: Optimized Cross rEActivity estimatioN

Sep 27, 2016·Journal of Chemical Information and Modeling·Paul Czodrowski, Wolf-Guido Bolick

Structural Exploration of Quinazolin-4(3H)-ones as Anticonvulsants: Rational Design, Synthesis, Pharmacological Evaluation, and Molecular Docking Studies

Sep 30, 2016·Archiv der Pharmazie·Vinod G Ugale, Sanjay B Bari

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

Oct 11, 2016·European Journal of Medicinal Chemistry·Dawid PanekBarbara Malawska

Epigenetic polypharmacology: from combination therapy to multitargeted drugs

Oct 19, 2016·Clinical Epigenetics·Angel R de Lera, A Ganesan

Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design

Oct 4, 2016·Journal of Medicinal Chemistry·Olivier Van der PoortenDirk Tourwé

Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression

Oct 18, 2016·ACS Chemical Neuroscience·Andrew P DegnanKevin W Gillman

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase

Oct 22, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Rita MeledduElias Maccioni

Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy

Oct 25, 2016·Future Medicinal Chemistry·M Amélia SantosSílvia Chaves

Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands

Aug 16, 2014·Bioorganic & Medicinal Chemistry·Luca SancinetoOriana Tabarrini

Light-controlled nitric oxide delivering molecular assemblies

Jun 18, 2010·Chemical Society Reviews·Salvatore Sortino

Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain

Jan 31, 2017·Pain·Camille LagardBruno Mégarbane

Computational polypharmacology: a new paradigm for drug discovery

Jan 10, 2017·Expert Opinion on Drug Discovery·Rajan ChaudhariShuxing Zhang

Computational Multitarget Drug Design

Feb 9, 2017·Journal of Chemical Information and Modeling·Weilin ZhangLuhua Lai

Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase

Feb 9, 2017·Journal of Medicinal Chemistry·Hui-Li NgWai-Keung Chui

First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases

Apr 14, 2017·Journal of Medicinal Chemistry·Mohamed SalahMartin Frotscher

Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease

May 16, 2017·Future Medicinal Chemistry·Damijan KnezStanislav Gobec

Design, synthesis and evaluation of novel cinnamic acid derivatives bearing N-benzyl pyridinium moiety as multifunctional cholinesterase inhibitors for Alzheimer's disease

Jun 7, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Jin-Shuai LanTong Zhang

Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex

Mar 30, 2017·Chemical Communications : Chem Comm·Suyan LiuFuyi Wang

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery

Mar 3, 2017·Journal of Medicinal Chemistry·Ewgenij ProschakDaniel Merk

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

Feb 22, 2017·Scientific Reports·Veronika TemmlDaniela Schuster

Prodigiosenes conjugated to tamoxifen and estradiol

Jun 20, 2017·Organic & Biomolecular Chemistry·Estelle MarchalAlison Thompson

New Modalities for Challenging Targets in Drug Discovery

Feb 12, 2017·Angewandte Chemie·Eric ValeurAlleyn T Plowright

Profiling donepezil template into multipotent hybrids with antioxidant properties

Mar 14, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Eva MezeiovaJan Korabecny

Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound

Mar 13, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irene SolaDiego Muñoz-Torrero

Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold

May 26, 2017·Biomedicines·Niall O KeelyMary J Meegan

A Systematic Review of Computational Drug Discovery, Development, and Repurposing for Ebola Virus Disease Treatment

Oct 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·James SchulerRam Samudrala

Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX

Jan 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aikaterini PeperidouClaudiu T Supuran

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents

Feb 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dawid PanekBarbara Malawska

Novel tetrahydroacridine derivatives with iodobenzoic acid moiety as multifunctional acetylcholinesterase inhibitors

Sep 26, 2017·Chemical Biology & Drug Design·Robert SkibińskiPaweł Szymański

Photo-induced anticancer activity and singlet oxygen production of prodigiosenes

Apr 13, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Huguette SavoieAlison Thompson

Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies

Jan 13, 2018·Medicinal Research Reviews·Mingyue ZhengHualiang Jiang

Nature's first "atypical opioids": Kratom and mitragynines

Mar 10, 2018·Journal of Clinical Pharmacy and Therapeutics·Robert B RaffaNEMA Research Group

Recent developments with rhodanine as a scaffold for drug discovery

Oct 12, 2017·Expert Opinion on Drug Discovery·Danylo KaminskyyRoman Lesyk

α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice

Aug 30, 2017·British Journal of Pharmacology·Indiara BruscoSara Marchesan Oliveira

New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease

Jun 6, 2018·Archiv der Pharmazie·Nina ChufarovaPaweł Szymański

Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives

Jun 7, 2018·Anais Da Academia Brasileira De Ciências·Luiz C S PinheiroNubia Boechat

Application of Docking Analysis in the Prediction and Biological Evaluation of the Lipoxygenase Inhibitory Action of Thiazolyl Derivatives of Mycophenolic Acid

Jul 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Evangelia TsolakiAnil K Saxena

Rational application of drug promiscuity in medicinal chemistry

Jul 19, 2018·Future Medicinal Chemistry·Yicheng Mei, Baowei Yang

Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

Mar 16, 2017·Antimicrobial Agents and Chemotherapy·Drishti AgarwalSatish K Awasthi

Multifunctional Compounds for Activation of the p53-Y220C Mutant in Cancer

Sep 20, 2018·Chemistry : a European Journal·Jessica J MillerTim Storr

A perspective on multi-target drug discovery and design for complex diseases

Jan 18, 2018·Clinical and Translational Medicine·Rona R RamsayMaria L Bolognesi

Dual aromatase-sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activity

Aug 31, 2007·Organic & Biomolecular Chemistry·Toby JacksonBarry V L Potter

Molecular docking, molecular modeling, and molecular dynamics studies of azaisoflavone as dual COX-2 inhibitors and TP receptor antagonists

Feb 27, 2018·Journal of Molecular Modeling·Murtuza HadianawalaBhaskar Datta

A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities

Apr 4, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Seyyed Mojtaba MousaviAli Mohammad Amani

Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials

Nov 22, 2018·Medicinal Research Reviews·Alexios N MatralisVassilis Aidinis

Molecular design opportunities presented by solvent-exposed regions of target proteins

Apr 20, 2019·Medicinal Research Reviews·Xiangyi JiangPeng Zhan

Hybrid Molecules Development: A Versatile Landscape for the Control of Antifungal Drug Resistance: A Review

Dec 12, 2018·Mini Reviews in Medicinal Chemistry·Chioma G AnusionwuXavier Y Mbianda

Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?

Apr 9, 2019·ChemMedChem·Angela De Simone, Andrea Milelli

Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity

Jun 5, 2019·Archiv der Pharmazie·Monika MarcinkowskaAnna Więckowska

Rational discovery of dual-indication multi-target PDE/Kinase inhibitor for precision anti-cancer therapy using structural systems pharmacology

Jun 18, 2019·PLoS Computational Biology·Hansaim LimLei Xie

Neoclassic drug discovery: the case for lead generation using phenotypic and functional approaches

Oct 2, 2013·Journal of Biomolecular Screening·Jonathan A Lee, Ellen L Berg

GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells

Dec 9, 2016·The Journal of Pharmacology and Experimental Therapeutics·Taruna JoshiMark A Giembycz

S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization

Dec 20, 2011·The Journal of Pharmacology and Experimental Therapeutics·Mark J MillanGilbert Lavielle

Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway

Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Sirui GuoQing Li

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors

Jul 14, 2017·ChemMedChem·James R HillAvril A B Robertson

Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases

Oct 21, 2018·Journal of Neural Transmission·Moussa B H Youdim

Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases

Oct 27, 2017·Current Medicinal Chemistry·Ana Cristina Lima LeiteGevanio Bezerra de Oliveira Filho

Anticandidal agent for multiple targets: the next paradigm in the discovery of proficient therapeutics/overcoming drug resistance

Nov 7, 2019·Future Medicinal Chemistry·Anubhuti Jha, Awanish Kumar

Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity

Nov 14, 2019·ChemMedChem·Benedetta FoisDanijel Kikelj

PIII /PV =O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles

Dec 24, 2019·Angewandte Chemie·Trevor V NykazaAlexander T Radosevich

Inhibitory Effects of Novel 7-Substituted 6-iodo-3-O -Flavonol Glycosides against Cholinesterases and β-secretase Activities, and Evaluation for Potential Antioxidant Properties

Sep 29, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emmanuel N AgboMalose J Mphahlele

Management of Dementia-Related Psychosis, Agitation and Aggression: A Review of the Pharmacology and Clinical Effects of Potential Drug Candidates

Feb 14, 2020·CNS Drugs·Monika MarcinkowskaMarcin Kołaczkowski

Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

Oct 4, 2019·The Journal of Antibiotics·Agnieszka WróbelDanuta Drozdowska

Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors

Mar 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Regina MartínezBeatriz de Pascual-Teresa

Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs.

Apr 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angelica ArtasensiLaura Fumagalli

Structure based design, synthesis and activity studies of small hybrid molecules as HDAC and G9a dual inhibitors

Oct 4, 2017·Oncotarget·Lanlan ZangPeng George Wang

Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds

Mar 10, 2016·Antimicrobial Agents and Chemotherapy·Aicha BoudharKevin S W Tan

Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents

Apr 22, 2020·Scientific Reports·Priti KumariRam Sagar

From combinations to multitarget-directed ligands: A continuum in Alzheimer's disease polypharmacology

Jun 20, 2020·Medicinal Research Reviews·Claudia AlbertiniMaria L Bolognesi

Epidermal Growth Factor Receptor and its Trafficking Regulation by Acetylation: Implication in Resistance and Exploring the Newer Therapeutic Avenues in Cancer.

Feb 8, 2020·Current Topics in Medicinal Chemistry·Manvendra KumarRaj Kumar

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

May 1, 2019·Medicinal Chemistry·Smita VermaS J S Flora

Multiple target-based pharmacophore design from active site structures

Dec 16, 2017·SAR and QSAR in Environmental Research·P KumarI Ghosh

A balancing act: using small molecules for therapeutic intervention of the p53 pathway in cancer

Sep 2, 2020·Chemical Society Reviews·Jessica J MillerTim Storr

Epigenetic-based cancer therapeutics: new potential HDAC8 inhibitors

Sep 5, 2020·Journal of Biomolecular Structure & Dynamics·Malihe HassanzadehMassoud Amanlou

Multi-targeted drug design strategies for the treatment of schizophrenia

Sep 12, 2020·Expert Opinion on Drug Discovery·Piotr StępnickiAgnieszka A Kaczor

NGP1-01 is a brain-permeable dual blocker of neuronal voltage- and ligand-operated calcium channels

May 31, 2006·Neurochemical Research·Cornelia KiewertJochen Klein

Efficacy and safety evaluation of a novel trioxaquine in the management of cerebral malaria in a mouse model

Jul 5, 2017·Malaria Journal·Onyango C OdhiamboFrancis W Muregi

Multiple target-centric strategy to tame inflammation

Aug 5, 2017·Future Medicinal Chemistry·Gaganpreet Kaur, Om Silakari

Synthesis of novel perillyl-dihydropyrimidinone hybrids designed for antiproliferative activity

Oct 6, 2018·MedChemComm·Vinicius VendrusculoDennis Russowsky

The Development of Novel Compounds Against Malaria: Quinolines, Triazolpyridines, Pyrazolopyridines and Pyrazolopyrimidines

Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luiz Carlos da Silva PinheiroNubia Boechat

Trimethoprim: An Old Antibacterial Drug as a Template to Search for New Targets. Synthesis, Biological Activity and Molecular Modeling Study of Novel Trimethoprim Analogs

Jan 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka WróbelDanuta Drozdowska

Natural products and Pharma 2011: strategic changes spur new opportunities

Sep 13, 2011·Natural Product Reports·Guy T Carter

Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5

Mar 20, 2009·Molecular Pharmacology·Spencer E HallNagarajan Vaidehi

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

Aug 26, 2017·Scientific Reports·Ulrike GarschaOliver Werz

Rational Drug Design of Antineoplastic Agents Using 3D-QSAR, Cheminformatic, and Virtual Screening Approaches

Jul 15, 2017·Current Medicinal Chemistry·Jelica VucicevicJohn B O Mitchell

Design, synthesis and molecular modeling study for some new 2-substituted benzimidazoles as dual inhibitors for VEGFR-2 and c-Met

Feb 13, 2018·Future Medicinal Chemistry·Heba A IbrahimKamilia M Amin

Does 'Strong Analgesic' Equal 'Strong Opioid'? Tapentadol and the Concept of 'µ-Load'

Sep 13, 2018·Advances in Therapy·Robert B RaffaThomas M Tzschentke

Promiscuous, Multi-Target Lupane-Type Triterpenoids Inhibits Wild Type and Drug Resistant HIV-1 Replication Through the Interference With Several Targets

May 4, 2018·Frontiers in Pharmacology·Luis M BedoyaJosé Alcamí

Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies

Dec 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eleni Pontiki, Dimitra Hadjipavlou-Litina

Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

Jun 27, 2019·Current Topics in Medicinal Chemistry·Viktoriya IvasivMaria L Bolognesi

Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure-activity relationship with a strong BBB permeability

Feb 14, 2019·Experimental & Molecular Medicine·Susoma JannatGil Hong Park

Prospects of multitarget drug designing strategies by linking molecular docking and molecular dynamics to explore the protein-ligand recognition process

Apr 25, 2020·Drug Development Research·Krishnankutty Chandrika SivakumarT P Sajeevan

Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells

Jul 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rossella FioravantiAntonello Mai

Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

Sep 5, 2020·Drug Design, Development and Therapy·Xolani H MakhobaOfentse J Pooe

Merged Tacrine-Based, Multitarget-Directed Acetylcholinesterase Inhibitors 2015-Present: Synthesis and Biological Activity.

Aug 23, 2020·International Journal of Molecular Sciences·Todd J EckroatSeth C Cowan

3-Amino-5-(indol-3-yl)methylene-4-oxo-2-thioxothiazolidine Derivatives as Antimicrobial Agents: Synthesis, Computational and Biological Evaluation

Sep 5, 2020·Pharmaceuticals·Volodymyr HorishnyPhaedra Eleftheriou

Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules

Jun 16, 2017·Scientific Reports·Seong-Hyun ParkInjae Shin

Molecular Consortia-Various Structural and Synthetic Concepts for More Effective Therapeutics Synthesis

Apr 13, 2018·International Journal of Molecular Sciences·Anna PawełczykLucjusz Zaprutko

Design of Diarylheptanoid Derivatives as Dual Inhibitors Against Class IIa Histone Deacetylase and β-amyloid Aggregation

Jul 19, 2018·Frontiers in Pharmacology·Liang-Chieh ChenKai-Cheng Hsu

Synthesis of substituted fluorobenzimidazoles as inhibitors of 5-lipoxygenase and soluble epoxide hydrolase for anti-inflammatory activity

May 8, 2018·Archiv der Pharmazie·B NandhaHazra Kuntal

Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs

Nov 10, 2018·Nature Communications·Hamid R NooriRainer Spanagel

Design, Synthesis, and In Vitro Biological Activities of a Bio-Oxidizable Prodrug to Deliver Both ChEs and DYRK1A Inhibitors for AD Therapy

Apr 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anaïs BarréVincent Levacher

Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist

Sep 22, 2018·Scientific Reports·Yu-Hua WangYu-Jun Wang

Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis

Jul 12, 2019·Frontiers in Pharmacology·Ryan D JonesGuang-Yu Yang

Epigenetic polypharmacology: A new frontier for epi-drug discovery

Jun 21, 2019·Medicinal Research Reviews·Daniela TomaselliAntonello Mai

New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chiara BrulloOlga Bruno

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease.

Feb 22, 2020·Scientific Reports·Julien LalutChristophe Rochais

Bifunctional ligand design for modulating mutant p53 aggregation in cancer

Feb 15, 2020·Chemical Science·Jessica J MillerTim Storr

LigBuilder V3: A Multi-Target de novo Drug Design Approach

Mar 18, 2020·Frontiers in Chemistry·Yaxia YuanLuhua Lai

Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities

Jun 27, 2020·Medicinal Research Reviews·Daniel A RodriguesCarlos A M Fraga

Recent Advances in Multi-target Anti-Alzheimer Disease Compounds (2013 Up to the Present)

Dec 7, 2018·Current Medicinal Chemistry·Ning WangShan He

Multi-Targeting Anticancer Agents: Rational Approaches, Synthetic Routes and Structure Activity Relationship

Jan 19, 2019·Anti-cancer Agents in Medicinal Chemistry·Harbinder SinghSahil Sharma

Elucidating Compound Mechanism of Action and Predicting Cytotoxicity Using Machine Learning Approaches, Taking Prediction Confidence into Account

Sep 5, 2019·Current Protocols in Chemical Biology·Georgios DrakakisAndreas Bender

2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities

Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olympia KouziDimitra Hadjipavlou-Litina

Exploring Biological Activity of 4-Oxo-4H -furo[2,3-h ]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15

Nov 27, 2019·Biomolecules·Malose J MphahleleItumeleng B Setshedi

In Vitro Evaluation and Docking Studies of 5-oxo-5H -furo[3,2-g ]chromene-6-carbaldehyde Derivatives as Potential Anti-Alzheimer's Agents

Nov 7, 2019·International Journal of Molecular Sciences·Malose J MphahleleEmmanuel N Agbo

Development of effective anti-influenza drugs: congeners and conjugates - a review

Oct 24, 2019·Journal of Biomedical Science·Jiun-Jie Shie, Jim-Min Fang

New flavonoid - N ,N -dibenzyl(N -methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

Dec 20, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Martín Estrada-ValenciaMaría Isabel Rodríguez-Franco

Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer's Disease Based on Systems Biology

Jan 25, 2020·Oxidative Medicine and Cellular Longevity·Sirui GuoQing Li

Pyrazolo[4,3-e ][1,2,4]triazolo[1,5-c ]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example

Aug 9, 2019·MedChemComm·Stephanie FedericoGiampiero Spalluto

Computational approach to suggest a new multi-target-directed ligand as a potential medication for Alzheimer's disease

Jan 29, 2019·Journal of Biomolecular Structure & Dynamics·Mahboobeh EslamiYounes Ghasemi

Selected 1,3-Benzodioxine-Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors.

Sep 15, 2020·ChemMedChem·Geum Seok JeongHoon Kim

A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor

Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul A FosterAtul Purohit

Search for new therapeutics against HIV-1 via dual inhibition of RNase H and integrase: current status and future challenges

Jan 6, 2021·Future Medicinal Chemistry·Harsha KharkwalSubhash Chander

Optimization of novel benzofuro[3,2-b]pyridin-2(1H)-one derivatives as dual inhibitors of BTK and PI3Kδ

Jan 4, 2019·European Journal of Medicinal Chemistry·Linyi LiuHua Xiang

In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications-A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B.

Jan 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosaria OttanàRosanna Maccari

Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ERα and VEGFR-2

Nov 2, 2018·European Journal of Medicinal Chemistry·Xinyu LiHua Xiang

Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease

Dec 20, 2020·Bioorganic & Medicinal Chemistry·Xueyang JiangHaopeng Sun

Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors

Oct 21, 2020·European Journal of Medicinal Chemistry·Amr K A BassGamal El-Din A Abuo-Rahma

Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies.

Sep 7, 2020·Bioorganic Chemistry·Stephanie WiltStevan Pecic

Discovery of novel oxoindolin derivatives as atypical dual inhibitors for DNA Gyrase and FabH

Oct 5, 2019·Bioorganic Chemistry·Yu-Shun YangHai-Liang Zhu

Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer's disease

Dec 19, 2020·European Journal of Medicinal Chemistry·Rongtian LinHeru Chen

Discovery of a multi-target compound for estrogen receptor-positive (ER+) breast cancer: Involvement of aromatase and ERs.

Dec 6, 2020·Biochimie·Cristina Ferreira AlmeidaCristina Amaral

Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy.

Dec 16, 2020·Bioorganic Chemistry·Neha UpadhyayC S Ramaa

Systematic Assessment of Fragment Identification for Multitarget Drug Design.

Dec 8, 2020·ChemMedChem·Steffen BrunstEwgenij Proschak

Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery?

Dec 22, 2020·Journal of Medicinal Chemistry·Angela De SimoneAndrea Milelli

Liver-Targeting Class I Selective Histone Deacetylase Inhibitors Potently Suppress Hepatocellular Tumor Growth as Standalone Agents

Oct 30, 2020·Cancers·Subhasish TapadarAdegboyega K Oyelere

Indole: The After Next Scaffold of Antiplasmodial Agents?

Nov 19, 2020·Drug Design, Development and Therapy·Abdrrahman Shemsu SururKaleab Asres

Drug Re-positioning Studies for Novel HIV-1 Inhibitors Using Binary QSAR Models and Multi-target-driven In Silico Studies.

Jan 7, 2021·Molecular Informatics·Berna Dogan, Serdar Durdagi

Discovery of Novel Pyrrolo[2,3-d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors.

Feb 16, 2021·Journal of Medicinal Chemistry·Xuewu LiangHong Liu

A new multifunctional hydroxytyrosol-fenofibrate with antidiabetic, antihyperlipidemic, antioxidant and antiinflammatory action

Oct 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yundong XieXiaoli Bian

Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells.

Jan 2, 2021·Viruses·Audrien Alves Andrade de SouzaElen Mello de Souza

BACE1 and cholinesterase inhibitory activities of compounds from Cajanus cajan and Citrus reticulata: an in silico study.

Feb 2, 2021·In Silico Pharmacology·Kayode Ezekiel Adewole, Ahmed Adebayo Ishola

Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer's action: Design, synthesis, crystal structure and in-vitro biological evaluation.

Feb 15, 2021·European Journal of Medicinal Chemistry·Shoaib ManzoorNasimul Hoda

Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter.

Feb 17, 2021·Journal of Medicinal Chemistry·José Luis DíazCarmen Almansa

Kojic acid-natural product conjugates as mushroom tyrosinase inhibitors

Jul 12, 2020·European Journal of Medicinal Chemistry·Morteza AshoorihaSaeed Emami

Novel diindoloazepinone derivatives as DNA minor groove binding agents with selective topoisomerase I inhibition: Design, synthesis, biological evaluation and docking studies.

Apr 10, 2020·Bioorganic Chemistry·Manasa KadagathurNeelima D Tangellamudi

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