Designer drugs in herbal aphrodisiacs

Forensic Science International : Synergy
B J VenhuisD De Kaste

Abstract

In the presented case three herbal aphrodisiacs (Libidfit, Satibo and Viamax) were investigated for the presence of regular pharmaceuticals against erectile dysfunction. However, high-performance liquid chromatography with diode array detection and mass spectrometry (HPLC-DAD-MS) and nuclear magnetic resonance (NMR) analyses revealed the presence of ingredients, having a molecular structure strongly resembling those of sildenafil (Viagra) and vardenafil (Levitra). The health risk posed by these analogous substances is high because they were found to be potent phosphodiesterase 5 (PDE5) inhibitors used in pharmacologically relevant quantities having no known safety profile. Based on structural and functional analogy these analogs represent a new class of designer drugs and should be taken off the market for being unapproved drug substances. In the Libidfit court case this was done successfully, setting a precedent.

References

Sep 21, 2000·Clinical Science·S F Campbell
Mar 14, 2002·International Journal of Impotence Research·I Saenz de TejadaE Bischoff
Sep 17, 2004·Food Additives and Contaminants·L Blok-TipD De Kaste
Sep 24, 2004·Magnetic Resonance in Chemistry : MRC·Choonshik ShinYoongho Lim
Nov 4, 2004·Journal of Pharmaceutical and Biomedical Analysis·Samuel R GratzKaren A Wolnik
Jan 9, 2007·Journal of Pharmaceutical and Biomedical Analysis·John C ReepmeyerD André d'Avignon
Feb 20, 2007·Journal of Pharmaceutical and Biomedical Analysis·Jiang WangJingkai Gu
Mar 17, 2007·Food Additives and Contaminants·H J ParkS W Kwon
May 27, 2008·British Journal of Pharmacology·J R Docherty

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Citations

Jun 4, 2016·Archives of Psychiatric Nursing·Sandra Lavelle
Dec 25, 2012·Journal of Pharmaceutical and Biomedical Analysis·Daniel J MansConnie M Gryniewicz-Ruzicka
Dec 26, 2008·Journal of Pharmaceutical and Biomedical Analysis·Stéphane BalayssacMarc-André Delsuc
Jul 25, 2009·BJU International·Jeff R Cortés-GonzálezAnders R Holmberg
Oct 14, 2010·Orvosi hetilap·Dezsö CsuporJudit Hohmann
Jan 20, 2009·Journal of Pharmaceutical and Biomedical Analysis·Connie M GryniewiczLucinda F Buhse
Jun 17, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Jiebiao GuoZijun Xiao
Nov 23, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·N M ReeuwijkM J Martena
Aug 2, 2017·Advanced Pharmaceutical Bulletin·Cristina MateescuAdina Elena Raducanu
Dec 22, 2016·Journal of Analytical Toxicology·Erica L BakotaDarshan R Phatak
Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Apr 28, 2020·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Yoko Ichikawa-KajiTakako Moriyasu
Mar 5, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Felicia AkuamoaToine F H Bovee

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