PMID: 9430738Feb 12, 1998Paper

Designing an effective immunocontraceptive

Journal of Reproductive Immunology
M G O'Rand, I A Lea

Abstract

The immunological inhibition of fertilization is the goal of gamete immunocontraception. To achieve this goal a gamete-specific antigen target must be defined and the presentation of the immunogen to the immune system must be clearly understood in order to elicit a defined immune response which will target the native gamete molecule. Almost 20 years ago C.B. Metz suggested six studies which would answer the questions necessary for the development of a successful immunocontraceptive, and although much work has gone into answering each of these questions, none has been completed. Hyaluronidase is an example of a well studied sperm antigen whose native, membrane bound form (PH-20) is a successful immunocontraceptive in female guinea pigs. However, it remains to be demonstrated that a successful native antigen can be a successful synthetic or recombinant gamete immunocontraceptive (GAMICON). The problem of converting a successful native contraceptive antigen into an effective synthetic or recombinant GAMICON is at the heart of the problem of GAMICON design. If the epitopes of native and synthetic immunogens are not the same, then can a conversion ever be made? One approach to understanding how to make this conversion is to use defi...Continue Reading

References

Mar 16, 1992·Biochemical and Biophysical Research Communications·G VanageS S Koide
Jul 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·C B MetzA E Castro
Sep 1, 1967·Archives of Biochemistry and Biophysics·M De SaleguiW Pigman
Jan 1, 1994·Reproduction, Fertility, and Development·M G O'Rand, E E Widgren
Sep 1, 1995·Biology of Reproduction·M KongM G O'Rand
Jul 17, 1996·Biochimica Et Biophysica Acta·I A LeaM G O'Rand
Jan 1, 1997·Annual Review of Immunology·S L Constant, K Bottomly
Dec 19, 1998·Journal of the American College of Cardiology·C BustosJ Egido

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Citations

Jan 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hong ShenW Mark Saltzman
Nov 2, 2001·Anatomia, histologia, embryologia·F SinowatzG Palma
Mar 17, 2004·Reproduction, Fertility, and Development·D J Kay, A L Kitchener
Mar 16, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher M HardyMalcolm A Lawson
Nov 13, 2004·Science·M G O'randA Jagannadha Rao

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