Designing and reporting clinical trials on treatments for cutaneous leishmaniasis

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Urbà GonzálezJorge Alvar

Abstract

Cutaneous leishmaniasis is considered to be one of the most neglected and serious parasitic infectious skin diseases in many developing countries. We have assessed the design and reporting of randomized, controlled trials evaluating treatments included in 2 Cochrane systematic reviews on cutaneous leishmaniasis. The analysis of the methodological quality identified some potential bias that can make it difficult to determine whether truly effective therapies exist for this disease. We found important weaknesses in the adequacy and transparency of randomization, loss of participants, causative Leishmania species, outcome measures, and follow-up times. Given these distorting effects on the evidence base, we propose guidelines for authors who wish to conduct clinical trials aimed at the development of effective therapies in cutaneous leishmaniasis. The recommendations in this report will hopefully deserve the attention of the World Health Organization and assist in the planning and prioritization of global strategies for improving the interpretation and replication of clinical research on cutaneous leishmaniasis.

Citations

May 3, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S AntinoriM Corbellino
May 28, 2011·Biological Trace Element Research·Claus HansenStefan Stürup
Feb 8, 2013·The New England Journal of Medicine·Afif Ben SalahMax Grogl
Nov 10, 2012·British Medical Bulletin·Michael P Barrett, Simon L Croft
Jul 27, 2012·The Journal of Antimicrobial Chemotherapy·Thomas P C DorloPeter J de Vries
Apr 5, 2013·PLoS Neglected Tropical Diseases·Piero OlliaroJorge Alvar
Feb 8, 2013·The American Journal of Tropical Medicine and Hygiene·Max GroglRichard J Sciotti
Jan 15, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Gustavo A S RomeroElza F Noronha
May 2, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark S Bailey
Feb 18, 2016·The Lancet Infectious Diseases·Chante KarimkhaniMohsen Naghavi
Oct 28, 2014·Expert Opinion on Pharmacotherapy·Shyam Sundar, Jaya Chakravarty
Mar 14, 2014·Expert Opinion on Drug Delivery·Esther MorenoSocorro Espuelas
Sep 10, 2013·Actas dermo-sifiliográficas·Y Torres GarciaR Botella Estrada
Mar 24, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alexandre L Neves SilvaMaria A Souza
Nov 28, 2012·Journal of Clinical Epidemiology·Evelina ChapmanXavier Bonfill
Nov 5, 2014·Antimicrobial Agents and Chemotherapy·Anke E KipThomas P C Dorlo
Sep 22, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S L Croft, P Olliaro
May 27, 2015·PloS One·Jaiberth Antonio Cardona-AriasLiliana López-Carvajal
Apr 17, 2012·PLoS Neglected Tropical Diseases·Rubén E Varela-MFaustino Mollinedo
Apr 1, 2011·Travel Medicine and Infectious Disease·P P A M van ThielP A Kager
Jan 30, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Juliana Saboia Fontenele e SilvaMarcus Tolentino Silva
Jan 10, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Mahmoodreza MoeinMohammad M Zarshenas
Nov 18, 2017·The Cochrane Database of Systematic Reviews·Julio Heras-MosteiroRogelio López-Vélez
Aug 8, 2015·The Cochrane Database of Systematic Reviews·Urbà GonzálezJorge Alvar
Feb 13, 2015·Clinical Microbiology Reviews·Gert Van der Auwera, Jean-Claude Dujardin
Apr 2, 2014·Antimicrobial Agents and Chemotherapy·Iris L K WongLarry M C Chow
May 26, 2011·Expert Review of Anti-infective Therapy·Emmanuel BottieauAlfons Van Gompel
Aug 28, 2015·Current Opinion in Infectious Diseases·Nathanial K Copeland, Naomi E Aronson
Aug 28, 2020·The Cochrane Database of Systematic Reviews·Mariona PinartJohn A Tweed
Dec 13, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Naomi AronsonAlan Magill
Dec 2, 2017·The Cochrane Database of Systematic Reviews·Julio Heras-MosteiroRogelio López-Vélez
Nov 10, 2018·The Australasian Journal of Dermatology·Vahid Mashayekhi GoyonloBita Kiafar
Jul 20, 2019·International Journal for Parasitology. Drugs and Drug Resistance·Diana CaridhaSimon L Croft

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