Designing casein-coated iron oxide nanostructures (CCIONPs) as superparamagnetic core-shell carriers for magnetic drug targeting

Progress in Biomaterials
Anamika SinghAnil Kumar Bajpai

Abstract

Magnetic drug targeting is a drug delivery system applicable to cancer treatment. Coated magnetic particles, called carriers, are very useful for delivering chemotherapeutic drugs. In the present research, casein-coated iron oxide nanocarriers (CCIONPs) of core shell nanostructure have been described as being applicable to magnetic drug targeting. The structure, morphology, and composition of prepared magnetic nanoparticles were determined by analytical techniques like Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Electron diffraction (ED), X-ray diffraction (XRD), Zeta potential, Dynamic light scattering (DLS), Mossbauer and Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), Vibrating sample magnetometery (VSM)) and in vitro cytotoxicity analysis. Magnetization studies of CCIONPs conducted at room temperature using a vibrating sample magnetometer suggested their superparamagnetic nature as having a saturation magnetization (Ms) of 64 emu g-1at an applied magnetic field of 5 kOe. The size of the magnetic polymeric nanoparticles was found to lie in the range of 73.9 ±0.36 nm, and the particles exhibited superparamagnetic behavior. The prepared...Continue Reading

References

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Citations

Feb 15, 2019·Applied Biochemistry and Biotechnology·Lorena Caixeta de Oliveira SimõesRoberto da Silva
Jan 16, 2022·International Journal of Biological Macromolecules·Parsa HaririMohammad Ali Faramarzi

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Methods Mentioned

BETA
scanning electron microscopy
transmission electron microscopy
electron diffraction
light scattering

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