Designing clinical trials for amblyopia

Vision Research
Jonathan M Holmes

Abstract

Randomized clinical trial (RCT) study design leads to one of the highest levels of evidence, and is a preferred study design over cohort studies, because randomization reduces bias and maximizes the chance that even unknown confounding factors will be balanced between treatment groups. Recent randomized clinical trials and observational studies in amblyopia can be taken together to formulate an evidence-based approach to amblyopia treatment, which is presented in this review. When designing future clinical studies of amblyopia treatment, issues such as regression to the mean, sample size and trial duration must be considered, since each may impact study results and conclusions.

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Citations

Jul 2, 2019·Therapeutic Advances in Ophthalmology·Marianne E F Piano, Anita J Simmers
Jan 23, 2018·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Tina Y GaoUNKNOWN Binocular Treatment of Amblyopia Using Videogames (BRAVO) Study Team

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