Designing Fast-Dissolving Orodispersible Films of Amphotericin B for Oropharyngeal Candidiasis

Pharmaceutics
Dolores R SerranoAikaterini Lalatsa

Abstract

Amphotericin B possesses high activity against Candida spp. with low risk of resistance. However, Amphotericin B's high molecular weight compared to other antifungal drugs, such as miconazole and clotrimazole, and poor water solubility hampers its efficacy at the physiological conditions of the oropharyngeal cavity (saliva pH, limited volume for dissolution) and thereby limits its clinical use in oropharyngeal candidiasis. We have prepared fast-dissolving orodispersible films with high loading (1% w/w) using solvent casting that enables amphotericin B to remain solubilised in saliva in equilibrium between the monomeric and dimeric states, and able to produce a local antifungal effect. Optimisation of the amphotericin B-loaded orodispersible films was achieved by quality by design studies combining dextran and/or maltodextrin as dextrose-derived-polymer film formers with cellulose-derived film formers (hydroxypropylmethyl/hydroxypropyl cellulose in a 1:4 weight ratio), sorbitol for taste masking, microcrystalline cellulose (Avicel 200) or microcrystalline cellulose-carboxymethylcellulose sodium (Avicel CL-611) for enhancing the mechanical strength of the film, and polyethylene glycol 400 and glycerol (1:1 w/w) as plasticizers. T...Continue Reading

References

May 1, 1984·Journal of Dental Research·F Lagerlöf, C Dawes
Dec 6, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H OkamotoK Danjo
Feb 9, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Suckjoon JunJohn Bechhoefer
Sep 26, 2007·Journal of Pharmaceutical Sciences·J J TorradoS Torrado-Santiago
Jun 7, 2008·International Journal of Antimicrobial Agents·Raquel EspadaJuan J Torrado
Jul 5, 2008·International Journal of Pharmaceutics·Raquel EspadaJuan J Torrado
Mar 13, 2009·AAPS PharmSciTech·Munish Kumar DhimanKrutika K Sawant
Apr 7, 2010·International Journal of Pharmaceutics·Valentina ReinerPeter Klaffenbach
Sep 26, 2012·Scientia pharmaceutica·Dhagla R ChoudharyAliasgar J Kundawala
Feb 27, 2013·International Journal of Pharmaceutics·Dolores R SerranoJuan J Torrado
Mar 18, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ana Filipa BorgesSérgio Simões
Apr 5, 2016·Drug Design, Development and Therapy·Xin LyuHong Hua
May 2, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dolores R SerranoAnne Marie Healy
Oct 19, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Muhammad IrfanAhmed Khan
Feb 16, 2017·Molecular Pharmaceutics·Miriam RolónMaria Auxiliadora Dea-Ayuela
Dec 3, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Dolores R SerranoAnne Marie Healy
May 11, 2018·Recent Patents on Drug Delivery & Formulation·Chaitrali Gijare, Ashwini Deshpande

❮ Previous
Next ❯

Citations

Apr 9, 2020·Pharmaceutics·Juan José TorradoJavier Capilla
Dec 31, 2019·Recent Patents on Drug Delivery & Formulation·Touraj EhtezaziAlison Hardy
Mar 2, 2021·International Journal of Biological Macromolecules·Murilo Santos PachecoMariana Agostini de Moraes
Mar 27, 2021·Drug Delivery and Translational Research·Sevda ŞenelGülçin Akca
Sep 4, 2020·Critical Reviews in Analytical Chemistry·Gabriel Davi MarenaMarlus Chorilli

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
Scanning Electron Microscopy

Software Mentioned

Spekwin32
Design Expert
Amebis Control

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.