Designing optogenetically controlled RNA for regulating biological systems

Annals of the New York Academy of Sciences
Mingxu You, Samie R Jaffrey

Abstract

Light-responsive proteins have been used in the field of optogenetics to control cellular functions. However, surprisingly, analogous approaches to regulate and alter the functions of RNA molecules by light remain underdeveloped. RNA aptamers and RNA devices can perform diverse intracellular functions and are important tools in synthetic biology. This report explores the challenges of and potential strategies for engineering light regulation into functional RNAs in cells. We discuss approaches for using existing light-regulated proteins and small molecules to control RNA function in living cells. In addition, applications of light-regulated RNAs for synthetic biology and for studying functions of endogenously expressed RNAs are discussed.

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Citations

Apr 6, 2016·Journal of Bioinformatics and Computational Biology·Jin LiYunlong Liu
Jul 6, 2016·Frontiers in Chemistry·Franziska Pfeiffer, Günter Mayer
Jun 8, 2017·Medicine, Conflict, and Survival·Lisa Eckenwiler, Matthew Hunt
Jun 6, 2017·Journal of Experimental Neuroscience·Cyril EleftheriouJose Fernando Maya-Vetencourt
Jul 2, 2019·Chemical Communications : Chem Comm·Daria V Berdnikova
Feb 14, 2020·ELife·Kelly A RotstanAndrej Luptak
Aug 17, 2020·Angewandte Chemie·Kewei RenMingxu You
Sep 30, 2021·Chemical Communications : Chem Comm·Daria V Berdnikova

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