Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria

ACS Applied Materials & Interfaces
Jan HynekKamil Lang

Abstract

Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One of the possible approaches to prevent surfaces from the biofilm formation is antimicrobial photodynamic inactivation based on the cytotoxic effect of singlet oxygen, O2(1Δg), a short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen. We synthesized porphyrin-based covalent organic frameworks (COFs) by Schiff-base chemistry. These novel COFs have a three-dimensional, diamond-like structure. The detailed analysis of their photophysical and photochemical properties shows that the COFs effectively produce O2(1Δg) under visible light irradiation, and especially three-dimensional structures have strong antibacterial effects toward Pseudomonas aeruginosa and Enterococcus faecalis biofilms. The COFs exhibit high photostability and broad spectral efficiency. Hence, the porphyrinic COFs are suitable candidates for the design of antibacterial coating for indoor applications.

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Citations

Aug 16, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·B Habermeyer, R Guilard
Sep 28, 2018·Organic & Biomolecular Chemistry·Jan HynekKamil Lang
Jun 13, 2019·Chemical Society Reviews·José L SeguraM Mar Ramos
Jul 11, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Stéphane BrandèsClaude P Gros
Jul 1, 2020·Frontiers in Bioengineering and Biotechnology·Yao WanLin Wang
Dec 14, 2018·Beilstein Journal of Nanotechnology·Jan HynekJan Demel
Jun 27, 2019·Advanced Healthcare Materials·Qingyan JiaWei Huang
Nov 26, 2020·Chemical Society Reviews·Da-Wen SunJi Ma
Dec 18, 2020·Chemical Society Reviews·Niklas Keller, Thomas Bein
Jan 22, 2021·Advanced Healthcare Materials·Arezoo EsrafiliAbhinav P Acharya
Apr 8, 2021·ACS Applied Materials & Interfaces·Jie FengYu-Bin Dong
May 29, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Natalya A VorotnikovaMichael A Shestopalov
Jun 5, 2021·ACS Applied Materials & Interfaces·Adrien SchlachterPierre D Harvey
Jul 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chunyang Liao, Sijin Liu
Jul 29, 2021·Biomaterials Science·Ahmad Reza BagheriJianbo Jia
Oct 4, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yun-Dan SunFu-Gen Wu
Nov 6, 2018·Journal of the American Chemical Society·Niklas KellerThomas Bein
Dec 2, 2021·Chemical Reviews·Austin M EvansWilliam R Dichtel

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