Designing proteins to combat disease: Cardiac troponin C as an example

Archives of Biochemistry and Biophysics
Jonathan P DavisShane D Walton

Abstract

Throughout history, muscle research has led to numerous scientific breakthroughs that have brought insight to a more general understanding of all biological processes. Potentially one of the most influential discoveries was the role of the second messenger calcium and its myriad of handling and sensing systems that mechanistically control muscle contraction. In this review we will briefly discuss the significance of calcium as a universal second messenger along with some of the most common calcium binding motifs in proteins, focusing on the EF-hand. We will also describe some of our approaches to rationally design calcium binding proteins to palliate, or potentially even cure cardiovascular disease. Considering not all failing hearts have the same etiology, genetic background and co-morbidities, personalized therapies will need to be developed. We predict designer proteins will open doors for unprecedented personalized, and potentially, even generalized medicines as gene therapy or protein delivery techniques come to fruition.

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Citations

May 10, 2016·Archives of Biochemistry and Biophysics·Brandon J Biesiadecki
Jan 10, 2017·Frontiers in Physiology·Jalal K SiddiquiJonathan P Davis
Nov 18, 2018·The Journal of General Physiology·Svetlana B TikunovaJonathan P Davis
Dec 27, 2016·Frontiers in Physiology·Hussam E SalhiBrandon J Biesiadecki
Feb 27, 2021·Journal of Molecular and Cellular Cardiology·Srboljub M MijailovichMichael Regnier
Jul 8, 2020·Journal of Chemical Information and Modeling·William H ColdrenSteffen Lindert
Apr 12, 2018·Biophysical Journal·Anthony D VetterJoseph M Metzger

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