Designing Recognition Molecules and Tailoring Functional Surfaces for In Vivo Monitoring of Small Molecules in the Brain

Accounts of Chemical Research
Limin Zhang, Yang Tian

Abstract

The in vivo analysis of chemical signals in brain extracellular fluid (ECF) using implanted electrochemical biosensors is a vital way to study brain functions and brain activity mapping. This approach offers excellent spatial (10-200 μm) and temporal (approximately second) resolution and the major advantage of long-term stability. By implantation of a microelectrode in a specific brain region, changes in the concentration of a variety of ECF chemical species can be monitored through applying a suitable electrical signal and, typically, recording the resulting Faradaic current. However, the high performance requirements for in vivo biosensors greatly limit our understanding of the roles that biomolecules play in the brain. Since a large number of biological species, including reactive oxygen species (ROS), metal ions, amino acids, and proteins, coexist in the brain and interact with each other, developing in vivo biosensors with high selectivity is a great challenge. Meanwhile, it is difficult to quantitatively determine target molecules in the brain because of the variation in the distinct environments for monitoring biomolecules in vitro and in vivo. Thus, there are large errors in the quantification of concentrations in the b...Continue Reading

References

Mar 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W A Mutch, A J Hansen
Dec 26, 2001·Chemical Reviews·G S Wilson, Y Hu
Jun 1, 2002·Analytical Chemistry·Yang TianTakeo Ohsaka
Jun 20, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Françoise Auchère, Frank Rusnak
Apr 28, 2005·Biosensors & Bioelectronics·George S Wilson, Raeann Gifford
Jun 19, 2008·Chemical Reviews·George S Wilson, Michael A Johnson
Jun 26, 2008·Chemical Reviews·Donita L RobinsonR Mark Wightman
Apr 13, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Monique A MakosMichael L Heien
Aug 13, 2011·Nature Reviews. Cancer·Bradley A WebbDiane L Barber
Jan 13, 2012·Accounts of Chemical Research·Meining ZhangLanqun Mao
Nov 15, 2013·Analytical Chemistry·James G RobertsLeslie A Sombers
Oct 28, 2015·Chemical Society Reviews·Ping YuLanqun Mao
Feb 24, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Ross D MiltonShelley D Minteer
Jan 10, 2017·Nature Nanotechnology·Chen ZhangJianlin Shi

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Citations

Jul 25, 2019·Analytical and Bioanalytical Chemistry·Hui GuGuoyue Shi
Jul 8, 2020·Angewandte Chemie·Yan-Ling Liu, Wei-Hua Huang
Jan 9, 2021·Frontiers in Microbiology·Xin ZhengXiaobo Hu
Nov 14, 2019·ACS Sensors·Cong XuLanqun Mao

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