Designing therapeutic strategies to combat severe acute respiratory syndrome coronavirus-2 disease: COVID-19.

Drug Development Research
Suman Rohilla

Abstract

A highly contagious coronavirus disease COVID-19 caused by a recently identified severe acute respiratory syndrome CoV-2 (SARS-CoV-2) initially detected in Wuhan, China has spread worldwide and become a major health crisis in the absence of specific vaccine or antiviral drugs. SARS-CoV-2 infection has resulted in overwhelming number of reported deaths. Unfortunately it is still spreading uncontrollably despite implementing stringent protective measures. Rapid development of effective therapeutic strategies for treatment and prevention of infection is crucially required. Although genomic characterization has assisted in unfolding various aspects of SARS-CoV-2 but development of specific antiviral drugs and vaccine against COVID-19 is still a worldwide challenge. Understanding the disease pathological course underlying the clinical manifestations of COVID-19 is imperative to identify the vital targets for drug development. SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) receptor to enter the host cell and primarily target type II alveolar cells. COVID-19 disease progression is associated with distressed immune functions and hyper active inflammatory system leading to development of cytokine storm which is a vital factor in...Continue Reading

References

Dec 3, 1998·Antimicrobial Agents and Chemotherapy·H L ShamD W Norbeck
Dec 15, 2000·Oncogene·S G Rane, E P Reddy
Nov 1, 2003·The Lancet Infectious Diseases·Andrea SavarinoRoberto Cauda
Sep 8, 2004·Biochemical and Biophysical Research Communications·Els KeyaertsMarc Van Ranst
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Aug 24, 2005·Virology Journal·Martin J VincentStuart T Nichol
Jan 28, 2006·The Lancet Infectious Diseases·Andrea SavarinoAntonio Cassone
May 2, 2008·Experimental Physiology·Yumiko ImaiJosef M Penninger
Apr 10, 2009·Expert Opinion on Drug Safety·Patricia Schirmer, Mark Holodniy
Jan 16, 2010·Biochemical Society Transactions·Michela Campagna, Carmen Rivas
Jan 16, 2010·Annals of the New York Academy of Sciences·Raphaela Goldbach-Mansky
Oct 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kátia Daniela da SilveiraMauro Martins Teixeira
Feb 2, 2011·PloS One·Elodie TeissierEve-Isabelle Pécheur
Mar 8, 2011·British Journal of Clinical Pharmacology·Eline A DuboisAdam F Cohen
Apr 26, 2013·Journal of Virology·Melissanne de WispelaerePriscilla L Yang
Aug 29, 2013·Antiviral Research·Julie BlaisingEve-Isabelle Pécheur
Oct 3, 2013·Antiviral Research·Yousuke FurutaDale L Barnard
Feb 28, 2015·Methods in Molecular Biology·Anthony R Fehr, Stanley Perlman
Jan 8, 2016·Journal of Virology·Eve-Isabelle PécheurStephen J Polyak
Sep 14, 2016·Drug Design, Development and Therapy·Lazaros I Sakkas
Feb 15, 2017·BMC Infectious Diseases·Shih-Chao LinChi-Chen Lin
Jun 6, 2017·Drug Design, Development and Therapy·Maria Gabriella RaimondoEnnio Giulio Favalli
Jul 1, 2017·Science Translational Medicine·Timothy P SheahanRalph S Baric
Aug 5, 2017·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Yousuke FurutaTakaaki Nakamura
Aug 5, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seema PatelTareq Abu-Izneid
Mar 27, 2018·Nature Reviews. Nephrology·Kenneth E BernsteinXiao Z Shen
Apr 17, 2019·Viruses·Egor P TchesnokovMatthias Götte
Jan 28, 2020·Lancet·Chen WangGeorge F Gao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Molecular Therapy. Methods & Clinical Development
Boxuan HuangYi-Zhou Jiang
Frontiers in Cell and Developmental Biology
Wenrui JiaZheng Zhou
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
Julianne D TwomeyBaolin Zhang
© 2021 Meta ULC. All rights reserved