Designs and methods for implementation research: Advancing the mission of the CTSA program

Journal of Clinical and Translational Science
Soohyun HwangJustin D Smith

Abstract

The US National Institutes of Health (NIH) established the Clinical and Translational Science Award (CTSA) program in response to the challenges of translating biomedical and behavioral interventions from discovery to real-world use. To address the challenge of translating evidence-based interventions (EBIs) into practice, the field of implementation science has emerged as a distinct discipline. With the distinction between EBI effectiveness research and implementation research comes differences in study design and methodology, shifting focus from clinical outcomes to the systems that support adoption and delivery of EBIs with fidelity. Implementation research designs share many of the foundational elements and assumptions of efficacy/effectiveness research. Designs and methods that are currently applied in implementation research include experimental, quasi-experimental, observational, hybrid effectiveness-implementation, simulation modeling, and configurational comparative methods. Examples of specific research designs and methods illustrate their use in implementation science. We propose that the CTSA program takes advantage of the momentum of the field's capacity building in three ways: 1) integrate state-of-the-science imp...Continue Reading

References

Aug 10, 2006·Clinical Trials : Journal of the Society for Clinical Trials·C Hendricks BrownJuan Peña
Mar 20, 2009·Annual Review of Public Health·C Hendricks BrownRobert D Gibbons
Feb 26, 2010·Academic Medicine : Journal of the Association of American Medical Colleges·Steven E ReisUNKNOWN National Clinical and Translational Science Awards Consortium
Jul 21, 2010·Implementation Science : IS·Amanda H SalanitroMonika M Safford
Mar 2, 2012·Clinical and Translational Science·Russell E Glasgow, David Chambers
Sep 18, 2012·Prevention Science : the Official Journal of the Society for Prevention Research·Kristen Hassmiller LichPatricia L Mabry
Jan 26, 2013·Implementation Science : IS·Helen I MeissnerBrian Mittman
May 10, 2013·Implementation Science : IS·Margaret B HarrisonValerie Angus
Jun 15, 2014·Administration and Policy in Mental Health·Justin D SmithKatherine Kavanagh
Jun 28, 2014·Biochemia Medica·Matthew S Thiese
Aug 6, 2014·American Journal of Preventive Medicine·Linda M CollinsJessica B Trail
Dec 8, 2014·Prevention Science : the Official Journal of the Society for Prevention Research·Peter A WymanC Hendricks Brown
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deborah K MayerRonald C Chen
Nov 26, 2015·Clinical and Translational Science·Moira InkelasBrian S Mittman
Feb 4, 2016·Statistics in Medicine·Getachew A DagneLei Liu
Feb 26, 2016·Implementation Science : IS·Mark S BauerJoAnn Kirchner
Mar 24, 2016·Implementation Science : IS·Borsika A RabinRussell E Glasgow
May 23, 2016·Systematic Reviews·Leila KahwatiCarol E Golin
Aug 3, 2016·Administration and Policy in Mental Health·Lindsey ZimmermanSteven E Lindley
Apr 7, 2017·Annual Review of Public Health·C Hendricks BrownGracelyn Cruden
Aug 18, 2017·Implementation Science : IS·Ross C BrownsonMallory Johnson
Feb 7, 2019·Frontiers in Public Health·Byron J PowellBryan J Weiner
Mar 25, 2019·Ethnicity & Disease·Moira McNultyC Hendricks Brown
Jul 1, 2019·Psychiatry Research·Christopher J MillerMarianne Pugatch
Aug 23, 2019·Psychiatry Research·Sara J LandesGeoffrey M Curran
Aug 23, 2019·Psychiatry Research·Alison B Hamilton, Erin P Finley

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Citations

May 16, 2020·BMJ : British Medical Journal·Lisa HirschhornAgnes Binagwaho
Jul 23, 2020·Journal of Clinical and Translational Science·Kathleen R Stevens, Jonathan N Tobin
Mar 13, 2021·Current HIV/AIDS Reports·Sheree R SchwartzStefan Baral

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Methods Mentioned

BETA
three hybrid

Software Mentioned

CTSA

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