PMID: 3748326Jul 1, 1986Paper

Desipramine induces yawning behaviour in rats

Neuropharmacology
E MogilnickaA Czyrak

Abstract

Yawning behaviour in rats injected subcutaneously with antidepressant drugs was studied by direct observation. Desipramine (0.1-30 mg/kg) elicited yawning that began 15-20 min after injection and lasted for 60 min, and the dose-response curve showed a bell-shaped form. Desipramine (10 mg/kg) elicited the maximal effect (mean number of yawns 13.6). Haloperidol (0.02 mg/kg), spiperone (0.2 mg/kg), pimozide (4 mg/kg), reserpine (7.5 mg/kg), alpha-methyl-p-tyrosine (250 mg/kg) and scopolamine (0.5 mg/kg) markedly reduced yawning induced by desipramine, whereas prazosin (1 mg/kg) and phenoxybenzamine (5 mg/kg) were without effect. These findings indicate that desipramine induces yawning by a dopaminergic mechanism, and that endogenous dopamine (DA) is necessary for its occurrence. Yawning was observed also after administration of imipramine, clomipramine, trazodone, its metabolite m-chlorophenylpiperazine and (+/-)sulpiride. These drugs given in a similar dose-range to desipramine produced a weaker effect than desipramine. Selective and potent inhibitors of the uptake of noradrenaline (NA) or 5-hydroxytryptamine (5-HT), (+)oxaprotiline and citalopram, did not elicit yawning. A possibility is considered that certain antidepressant dr...Continue Reading

Citations

Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·A Bourson, P C Moser
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·H KimuraT Furukawa
Jul 27, 2001·Cephalalgia : an International Journal of Headache·D E Jacome
Jul 21, 2009·Primary Care Companion to the Journal of Clinical Psychiatry·Sarita Pal, Prasad R Padala
Jun 29, 2010·Psychoneuroendocrinology·Agnieszka Nikiforuk, Piotr Popik
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Sergio TufikMarco T de Mello

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