Desipramine inhibits histamine H1 receptor-induced Ca2+ signaling in rat hypothalamic cells.

PloS One
Ji-Ah KangSe-Young Choi

Abstract

The hypothalamus in the brain is the main center for appetite control and integrates signals from adipose tissue and the gastrointestinal tract. Antidepressants are known to modulate the activities of hypothalamic neurons and affect food intake, but the cellular and molecular mechanisms by which antidepressants modulate hypothalamic function remain unclear. Here we have investigated how hypothalamic neurons respond to treatment with antidepressants, including desipramine and sibutramine. In primary cultured rat hypothalamic cells, desipramine markedly suppressed the elevation of intracellular Ca(2+) evoked by histamine H1 receptor activation. Desipramine also inhibited the histamine-induced Ca(2+) increase and the expression of corticotrophin-releasing hormone in hypothalamic GT1-1 cells. The effect of desipramine was not affected by pretreatment with prazosin or propranolol, excluding catecholamine reuptake activity of desipramine as an underlying mechanism. Sibutramine which is also an antidepressant but decreases food intake, had little effect on the histamine-induced Ca(2+) increase or AMP-activated protein kinase activity. Our results reveal that desipramine and sibutramine have different effects on histamine H1 receptor s...Continue Reading

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Citations

Feb 20, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiamei LianChao Deng
Jan 8, 2015·Psychopharmacology·Cristiani F BortolattoCristina W Nogueira

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Methods Mentioned

BETA
mechanical dissociation
PCR

Software Mentioned

Microcal Origin
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