PMID: 8454900Apr 1, 1993Paper

Desmocollins I and II are recognized by certain sera from patients with various types of pemphigus, particularly Brazilian pemphigus foliaceus

The Journal of Investigative Dermatology
M DmochowskiT Nishikawa

Abstract

Recently, it has been shown that desmoglein, pemphigus foliaceus target antigen, and a 130-kD pemphigus vulgaris antigen belong to the cadherin family of cell adhesion molecules. We tried to determine whether desmocollins I/II, other cadherin-like transmembranous glycoproteins present in desmosomes, are also recognized by pemphigus autoantibodies of the IgG class. We examined 16 pemphigus vulgaris sera, 15 pemphigus foliaceus sera, 15 Brazilian pemphigus foliaceus sera, five bullous pemphigoid sera, and 65 normal sera. Four (25%) pemphigus vulgaris sera, one (7%) pemphigus foliaceus serum, eight (53%) Brazilian pemphigus foliaceus sera, and three (5%) normal sera reacted with desmocollins I/II on immunoblots of bovine desmosome preparation. The affinity-purified desmocollins I/II pemphigus autoantibodies were shown to bind the epidermal cell surface by indirect immunofluorescence. Immunoblot analysis revealed one pemphigus vulgaris serum, one Brazilian pemphigus foliaceus serum, and one normal serum recognizing a recombinant protein produced by a desmocollin cDNA clone. Moreover, immunoblot analysis of reactivity of a Brazilian pemphigus foliaceus serum with recombinant proteins produced by deletion mutants of the desmocollin c...Continue Reading

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Citations

Jun 17, 2006·Journal of Cutaneous Pathology·Alessandro LanzaFernando Gombos
Sep 24, 2011·Autoimmunity·Sergei A Grando
Feb 18, 2012·Oral Diseases·N CirilloS A Grando
Mar 19, 2013·PloS One·Mina Kalantari-DehaghiSergei A Grando
Jan 14, 2016·Pediatric Dermatology·Shamir GellerEli Sprecher
Jan 10, 2018·Clinical Reviews in Allergy & Immunology·Robert PollmannMichael Hertl
Apr 12, 2001·The British Journal of Dermatology·K E HarmanM M Black
Mar 23, 2007·Archives of Dermatological Research·Nicola CirilloAlessandro Lanza
Apr 24, 2007·Virchows Archiv : an International Journal of Pathology·Nicola CirilloAlessandro Lanza
Oct 1, 1995·The British Journal of Dermatology·M DmochowskiD R Garrod
Feb 2, 2013·Cell Communication & Adhesion·Nicola Cirillo, Badr A Al-Jandan
Apr 24, 2013·The British Journal of Dermatology·A UedaT Hashimoto
Mar 22, 2015·Cell and Tissue Research·Sara N Stahley, Andrew P Kowalczyk
Oct 28, 2016·Journal of Cellular Physiology·Antonio CelentanoNicola Cirillo
Mar 4, 2006·Experimental Dermatology·Sergei A Grando
Aug 1, 1994·The British Journal of Dermatology·S Burge
Apr 1, 1996·Journal of Dermatological Science·T HashimotoT Nishikawa
Aug 1, 1995·The Journal of Investigative Dermatology·A P KowalczykK J Green
Aug 1, 1994·Journal of the American Academy of Dermatology·T P ChorzelskiS Jabłońska

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