Desmoglein-2 as a prognostic and biomarker in ovarian cancer.

Cancer Biology & Therapy
Jiho KimAndré Lieber

Abstract

Greater than 80% of all cancer cases are carcinomas, formed by the malignant transformation of epithelial cells. One of the key features of epithelial tumors is the presence of intercellular junctions, which link cells to one another and act as barriers to the penetration of molecules. This study assessed the expression of desmoglein-2, an epithelial junction protein, as a prognostic and diagnostic biomarker for ovarian cancer. Ovarian cancer sections were stained for DSG2 and signal intensity was correlated to cancer type and grade. DSG2 immunohistochemistry signals and mRNA levels were analyzed in chemo-resistant and chemo-sensitive cases. Ovarian cancer patient serum levels of shed DSG2 were correlated to disease-free and overall survival. Primary ovarian cancer cells were used to study DSG2 levels as they changed in response to cisplatin treatment. DSG2 expression was found to be positively correlated with cancer grade. Ovarian cancer patients with high serum levels of shed DSG2 fared significantly worse in both progression-free survival (median survival of 16 months vs. 26 months, p = .0023) and general survival (median survival of 37 months vs. undefined, p < .0001). A subgroup of primary chemotherapy-resistant cases had ...Continue Reading

References

Feb 1, 1993·Critical Reviews in Oncology/hematology·B D Curti
Apr 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G J RustinH E Lambert
Jul 10, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·J M Anderson
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert F OzolsUNKNOWN Gynecologic Oncology Group
Dec 14, 2004·The New England Journal of Medicine·Stephen A Cannistra
Jul 19, 2005·The Journal of Pathology·Karin BiedermannGisela Keller
Jul 25, 2006·Nature Reviews. Cancer·Andrew I Minchinton, Ian F Tannock
Aug 8, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Masakazu YashiroKosei Hirakawa
Sep 5, 2006·Cancer Research·Jason J Christiansen, Ayyappan K Rajasekaran
Sep 15, 2007·Biochimica Et Biophysica Acta·David Garrod, Martyn Chidgey
Nov 7, 2008·Molecular Biology of the Cell·Jodi L KlessnerKathleen J Green
Dec 3, 2008·Molecular & Cellular Proteomics : MCP·Cynthia KukEleftherios P Diamandis
Dec 9, 2008·Biochimica Et Biophysica Acta·Julian A Guttman, B Brett Finlay
Apr 1, 2009·Seminars in Oncology·Michael V Seiden
May 22, 2009·Cell Adhesion & Migration·Donna Brennan, Mÿ G Mahoney
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·James M Anderson, Christina M Van Itallie
Jul 29, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Anniina KoskiAkseli Hemminki
Oct 5, 2010·Lancet·Gordon J S RustinUNKNOWN EORTC 55955 investigators
Dec 15, 2010·Nature Medicine·Hongjie WangAndré Lieber
Jan 29, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gordon John Sampson RustinUNKNOWN Gynecological Cancer Intergroup
Oct 13, 2011·Cancer Research·Ines BeyerAndré Lieber
Apr 27, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ines BeyerAndré Lieber
Jan 1, 2013·Tissue Barriers·Ines BeyerAndré Lieber
Jun 2, 2015·Molecular Therapy. Methods & Clinical Development·Maximilian RichterAndré Lieber
Oct 16, 2015·British Journal of Cancer·Steffen OrmannsThomas Knösel
Mar 10, 2017·Molecular Carcinogenesis·Katharina HützVolker Spindler
Jan 7, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Christine E WangSuzie H Pun
Jul 28, 2019·Journal of Cellular Biochemistry·Hongyu XieKang Li
Jan 17, 2020·Journal of Medical Virology·Lukasz Kuryk, Anne-Sophie W Møller

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Methods Mentioned

BETA
xenograft
biopsies
RNA-seq
biopsy
flow cytometry
ELISA
RNAseq

Software Mentioned

GISTIC
Leica Application Suite
Graphpad Prism
cBioPortal
Visiopharm
ImageJ

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