Desmoglein-2 overexpression predicts poor prognosis in hepatocellular carcinoma patients

European Review for Medical and Pharmacological Sciences
C-P HanY-S Liu

Abstract

Desmoglein-2 (Dsg2) plays a crucial role in the assembly and adhesion of desmosomes. The absent or aberrant expression of Dsg2 was reported to be associated with the progression of varies human cancers. However, the expression of Dsg2 in hepatocellular carcinoma (HCC) and its association with tumor prognosis is still unknown. The aim of this study was to evaluate the expression level of Dsg2 in HCC and of the correlation between Dsg2 expression and clinicopathological variables. A total of 104 patients diagnosed with HCC were enrolled in this study. Real time-quantitative PCR (RT-qPCR) and Western blot were performed to determine the expression level of Dsg2 in HCC tumor tissues and matched noncancerous tissues. Cell proliferation and cell cycle were measured by cell counting kit-8 (CCK-8) assay and flow-cytometry assay, respectively. Our results revealed that Dsg2 expression was significantly higher in HCC tumor tissues than in matched noncancerous tissues (p < 0.01), positively correlated with tumor size (p = 0.035) and tumor stage (p = 0.021). Univariate and multivariate analyses demonstrated Dsg2 expression was an independent prognostic factor for overall survival. Meanwhile, we found knockdown the expression of Dsg2 using ...Continue Reading

Citations

Sep 23, 2020·International Journal of Molecular Sciences·Lobke C M HensenSelas T F Bots
Jan 1, 2021·International Journal of Genomics·Jun WangYanbin Li
Oct 12, 2021·Frontiers in Cell and Developmental Biology·Lisa MüllerRené Keil

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