Desmoplastic small round cell tumor of the kidney

The American Journal of Surgical Pathology
Min-Cheng SuYuan-Chung Chu

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive, malignant tumor usually present with widespread abdominal serosal involvement. Isolated cases occur in limbs, head and neck, and brain. We present a case of primary DSRCT of the kidney in a 41-year-old man. The tumor showed morphologic, immunohistochemical, and molecular characteristics similar to DSRCTs arising in other sites. Epithelial and mesenchymal markers were coexpressed in the tumor cells. RT-PCR analysis showed EWS-WT1 fusion transcripts resulting from the t(11;22)(p13;q12) reciprocal translocation. DSRCT should be considered in the differential diagnosis of small blue round cell tumors of the kidney.

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Citations

Apr 7, 2007·The American Journal of Surgical Pathology·Larry L WangHarry Kozakewich
Jul 16, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rogério Cardoso da SilvaCarlos E Bacchi
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Jul 25, 2020·Diagnostic Pathology·Dilek Ertoy BaydarYarkin Kamil Yakupoglu

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