PMID: 2123565Dec 1, 1990Paper

Desmopressin and indomethacin therapy for nephrogenic diabetes insipidus in patients receiving lithium carbonate

Southern Medical Journal
R S Weinstock, A M Moses

Abstract

Individuals receiving lithium carbonate commonly have nephrogenic diabetes insipidus. There is no effective and practical treatment for this condition. We have found that large doses of desmopressin (DDAVP) may provide effective therapy without adverse effects. A recent report showed that indomethacin improved nephrogenic diabetes insipidus that had persisted after the lithium therapy was discontinued. We have provided additional evidence that indomethacin may be effective, even when treatment with lithium is continued. We also have shown that indomethacin together with desmopressin can markedly decrease polyuria, though indomethacin must be used with care because it may impair renal function.

Citations

Nov 1, 1995·Critical Care Medicine·C BurkeJ Castellano
Aug 3, 2013·Clinical Medicine : Journal of the Royal College of Physicians of London·C KamathL D Premawardhana
Feb 15, 2013·American Journal of Physiology. Renal Physiology·Bellamkonda K Kishore, Carolyn M Ecelbarger
Feb 24, 2016·Indian Journal of Endocrinology and Metabolism·Sanjay KalraHarshad Malve
Jul 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·E J Gray, E J Dierks
Dec 18, 2013·Biochimica Et Biophysica Acta·Marleen L A Kortenoeven, Robert A Fenton
Apr 3, 2012·Journal of Geriatric Psychiatry and Neurology·Soham RejKenneth Shulman
Apr 16, 2005·The Journal of Pharmacy and Pharmacology·Melkamu GetieReinhard H H Neubert
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Apr 5, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Camelia G GarofeanuWilliam F Clark

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