PMID: 9539304Apr 16, 1998Paper

Desmopressin and low-dose ACTH test in rheumatoid arthritis

European Journal of Endocrinology
L FoppianiM Giusti

Abstract

To ascertain whether a different regulation and sensitivity of the hypothalamic-pituitary-adrenal axis exists and whether a type of cortisol resistance is present in rheumatoid arthritis (RA) patients, a chronic disease in whose pathogenesis modifications of the steroid milieu are involved. We studied the basal and dynamic response of ACTH and adrenal steroids to various stimuli acting on the hypophysis or directly on the adrenal gland. We studied ten RA patients (39.8 +/- 7.4 (S.D.) years), defined according to the American Rheumatism Association, and seven healthy control patients (34.1 +/- 9.6 (S.D.) years). All subjects underwent testing, in random order, with placebo, desmopressin (DDAVP) (10 microg i.v.), ovine corticotropin-releasing hormone (oCRH) (1 microg/kg body weight) and low-dose ACTH (5 microg i.v.), during the follicular phase of two different menstrual cycles. Blood samples were collected at different times for ACTH and adrenal steroids assay. Baseline estradiol (E2), testosterone and IGF-I levels were also evaluated. All subjects collected urine specimens for 24 h urine free cortisol (UFC). No difference in E2, testosterone or UFC was found between RA patients and controls. IGF-I levels were significantly (P <...Continue Reading

Citations

Jul 23, 1999·Annals of the New York Academy of Sciences·M MarcenaroM Cutolo
Jul 13, 2002·Annals of the New York Academy of Sciences·M WahleC G O Baerwald
Jul 3, 2008·Annals of the Rheumatic Diseases·L A MandlE W Karlson
Apr 24, 2014·Annals of the New York Academy of Sciences·Alfonse T MasiJean C Aldag
Feb 1, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·A M Eijsbouts, E P Murphy
Jun 19, 2004·Stress : the International Journal on the Biology of Stress·Signe F BomholtRuth E Blackburn-Munro
Nov 6, 2003·Biological & Pharmaceutical Bulletin·Yoshiharu KobayashiMikio Nishida
Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·M MoroF Cavagnini
Nov 21, 2000·Rheumatic Diseases Clinics of North America·K S Kanik, R L Wilder

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