Desmopressin for treating nocturia in men

BJU International
Julia HanPhilipp Dahm

Abstract

To assess the effects of desmopressin as compared to other interventions in the treatment of nocturia in men. We performed a comprehensive search using multiple databases and abstract proceedings with no restrictions on the language of publication or publication status, up until August 2017. We included randomised or quasi-randomised trials. Inclusion criteria were men with nocturia defined as one or more voids per night. Two review authors independently examined full-text reports, identified relevant studies, assessed the eligibility of studies for inclusion, extracted data, and assessed risk of bias. We performed statistical analyses using a random-effects model and assessed the quality of the evidence (QoE) according to Grades of Recommendation, Assessment, Development and Evaluation (GRADE). We included 14 studies with 2 966 randomised men across five comparisons (we did not include one comparison [desmopressin vs behaviour modification] in the abstract due to a lack of data with regard to primary outcomes). Desmopressin vs placebo: based on short-term follow-up (≤3 months), desmopressin may have a similar effect on the number of nocturnal voids (mean difference [MD] -0.46, 95% confidence interval [CI] -0.94 to 0.01; low Qo...Continue Reading

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Citations

Oct 22, 2019·PLoS Medicine·Michael FralickAaron S Kesselheim
Jun 9, 2020·Current Urology Reports·Eric G Katz, Lara S MacLachlan

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