Desmosomes: adhesive strength and signalling in health and disease

The Biochemical Journal
Helen A ThomasonDavid Garrod

Abstract

Desmosomes are intercellular junctions whose primary function is strong intercellular adhesion, known as hyperadhesion. In the present review, we discuss how their structure appears to support this function as well as how they are assembled and down-regulated. Desmosomal components also have signalling functions that are important in tissue development and remodelling. Their adhesive and signalling functions are both compromised in genetic and autoimmune diseases that affect the heart, skin and mucous membranes. We conclude that much work is required on structure-function relationships within desmosomes in vivo and on how they participate in signalling processes to enhance our knowledge of tissue homoeostasis and human disease.

References

Jun 1, 1978·The British Journal of Dermatology·L A Diaz, C L Marcelo
Dec 1, 1984·The Journal of Cell Biology·F M WattD R Garrod
Aug 1, 1984·The Journal of Clinical Investigation·J R StanleyC Thivolet
Oct 1, 1994·The Journal of Investigative Dermatology·M AmagaiJ R Stanley
May 1, 1994·Biophysical Chemistry·A P KowalczykK J Green
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·A J NorthD R Garrod
Dec 15, 1996·Developmental Biology·C BierkampR Kemler
Feb 24, 1997·The Journal of Cell Biology·J E LewisM J Wheelock
Jun 25, 1998·Cell Adhesion and Communication·L S AmarN Forest
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·C TselepisD Garrod
Aug 12, 1998·The Journal of Investigative Dermatology·V A BotchkarevR Paus
Sep 4, 1998·Science·T C HeK W Kinzler
Sep 17, 1998·Journal of the American Academy of Dermatology·L Carvajal-Huerta
Jan 15, 1999·Human Molecular Genetics·D K ArmstrongA E Hughes
Apr 4, 2000·The Journal of Cell Biology·M HatzfeldU Vinzens
Apr 18, 2000·The Journal of Cell Biology·E CharpentierP Cowin

❮ Previous
Next ❯

Citations

Feb 2, 2012·Cell and Tissue Research·Sebastian KantClaudia A Krusche
May 7, 2013·Trends in Molecular Medicine·Hin-Ting WanC Yan Cheng
Jul 31, 2013·Trends in Cell Biology·Oxana Nekrasova, Kathleen J Green
Apr 22, 2011·Nature Reviews. Cancer·Rachel L Dusek, Laura D Attardi
Aug 14, 2013·The Journal of Cell Biology·Adi D DubashKathleen J Green
May 23, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yuan Qiu, Hua Yang
Jan 13, 2012·Molecular Biology of the Cell·Kaelyn D Sumigray, Terry Lechler
Nov 1, 2011·Pharmacological Reviews·C Yan Cheng, Dolores D Mruk
Jan 10, 2013·The Journal of Clinical Investigation·Volker SpindlerJens Waschke
Mar 26, 2013·The Journal of Clinical Investigation·Robert M HarmonKathleen J Green
Jan 13, 2012·BMC Developmental Biology·Alexander GoonesingheDavid Garrod
Sep 22, 2012·BMC Gastroenterology·Klaus MönkemüllerPeter Malfertheiner
Jul 27, 2012·Journal of Cell Science·Masataka SaitoAndrew P Kowalczyk
Feb 3, 2011·Journal of Cell Science·Andrew H JheonOphir D Klein
Feb 6, 2014·PloS One·Sara N StahleyAndrew P Kowalczyk
Jun 20, 2014·PloS One·Francisco de Borja CallejasJoaquim Mullol
Dec 18, 2013·Nature Protocols·Hiromitsu TanakaTomoo Hirano
Apr 16, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M C RusuA C Didilescu
Aug 17, 2011·The Journal of Cell Biology·Kaelyn D SumigrayTerry Lechler
Nov 7, 2012·The Journal of Cell Biology·Jing ChenKathleen J Green
Mar 4, 2015·The Journal of Cell Biology·Lauren V AlbrechtKathleen J Green
Jan 30, 2015·Cancers·Louise Brown, Hong Wan
Jul 1, 2014·Cell Communication & Adhesion·David Garrod, Lydia Tabernero
Jan 28, 2014·Cell Communication & Adhesion·Volker Spindler, Jens Waschke
Jan 28, 2014·Cell Communication & Adhesion·Mechthild HatzfeldRené Keil
Jan 28, 2014·Cell Communication & Adhesion·Mohamed Berika, David Garrod
Jul 17, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Andrew H JheonOphir D Klein
May 5, 2012·Trends in Cell Biology·Julia BraschLawrence Shapiro
Feb 22, 2012·Progress in Lipid Research·Peter J Quinn
Sep 29, 2011·Experimental Cell Research·Brett J RobertsJames K Wahl
Jul 15, 2011·The Journal of Allergy and Clinical Immunology·Chang XiaoDonna E Davies
Mar 29, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Volker Spindler, Jens Waschke
Jul 26, 2013·The Journal of Investigative Dermatology·Jennifer L KoetsierLisa M Godsel
Jul 20, 2012·The Journal of Investigative Dermatology·Gustavo FloresLuis A Diaz
Sep 24, 2013·The Journal of Investigative Dermatology·Dana K TuckerAndrew P Kowalczyk
Oct 14, 2011·The Journal of Investigative Dermatology·Ryan P Hobbs, Kathleen J Green
Jan 21, 2014·The Journal of Investigative Dermatology·Volker SpindlerJens Waschke
Jun 15, 2011·The British Journal of Dermatology·H ErkenM Tekin
Oct 13, 2011·The Journal of Pathology·Matthew A BrookeDavid P Kelsell
Sep 21, 2011·The British Journal of Dermatology·G PetrofJ A McGrath
Feb 20, 2014·Medicinal Research Reviews·Jens Waschke, Volker Spindler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

The Journal of Pathology
Matthew A BrookeDavid P Kelsell
Cold Spring Harbor Perspectives in Biology
K J GreenLisa M Godsel
Cold Spring Harbor Perspectives in Biology
Emmanuella DelvaA P Kowalczyk
© 2021 Meta ULC. All rights reserved