Desmosomes and disease: pemphigus and bullous impetigo

Current Opinion in Cell Biology
Aimee S PayneJ R Stanley

Abstract

Desmosomal cadherins are the pathophysiologic targets of autoimmune or toxin-mediated disruption in the human diseases pemphigus and bullous impetigo (including its generalized form, called staphylococcal scalded skin syndrome). Experiments exploiting the production of both pathogenic and nonpathogenic antidesmoglein antibodies in pemphigus patients' sera have afforded data that make an invaluable contribution towards identifying the functional domains of the desmogleins involved in intercellular adhesion. Conformational epitopes of antidesmoglein autoantibodies in pemphigus patients' sera and the specific cleavage site of desmoglein 1 by exfoliative toxin have been identified, implicating the N-terminal extracellular domains of the desmogleins as critical regions for controlling intercellular adhesion. Furthermore, the development of active autoimmune mouse models for pemphigus allows in vivo characterization of the disease and its pathogenesis. These studies offer new insight into the potential mechanisms of acantholysis in pemphigus and staphylococcal-associated blistering disease, with implications for the role of desmogleins in desmosomal structure and function.

References

Sep 1, 1983·The Journal of Investigative Dermatology·D L Swanson, M V Dahl
Jun 1, 1995·The Journal of Investigative Dermatology·M AmagaiT Nishikawa
Aug 1, 1995·The Journal of Investigative Dermatology·A P KowalczykK J Green
Mar 23, 1995·Nature·L ShapiroW A Hendrickson
Jun 1, 1997·Current Opinion in Genetics & Development·C Ruhrberg, F M Watt
Oct 27, 1997·The Journal of Investigative Dermatology·X DingJ A Fairley
Jan 10, 1998·The Journal of Investigative Dermatology·Y ShirakataK Hashimoto
Feb 18, 1999·The Journal of Clinical Investigation·M G MahoneyJ R Stanley
Feb 20, 1999·Journal of the American Academy of Dermatology·M AmagaiT Nishikawa
May 8, 1999·The Journal of Investigative Dermatology·X DingZ Liu
Jan 13, 2000·Archives of Dermatology·J N Mehta, A G Martin
Mar 11, 2000·The Journal of Clinical Investigation·M AmagaiT Nishikawa
Jul 7, 2000·The New England Journal of Medicine·H WuJ R Stanley
Nov 9, 2000·The Journal of Investigative Dermatology·Y FuteiT Nishikawa
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M SekiguchiM Amagai
Nov 17, 2001·The Journal of Investigative Dermatology·C D Andl, J R Stanley
Feb 20, 2002·The Journal of Investigative Dermatology·Manabu OhyamaTakeji Nishikawa
Apr 20, 2002·Science·Titus J BoggonLawrence Shapiro
May 2, 2002·The Journal of Investigative Dermatology·Masayuki AmagaiJohn R Stanley
Jul 3, 2002·The Journal of Clinical Investigation·Yasushi HanakawaJohn R Stanley
Dec 18, 2002·The Journal of Investigative Dermatology·Leena PulkkinenMy G Mahoney
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuyuki TsunodaMasayuki Amagai
Feb 13, 2003·Journal of the American Academy of Dermatology·Masayuki Amagai

❮ Previous
Next ❯

Citations

Feb 6, 2007·Archives of Dermatological Research·Cassian SitaruDetlef Zillikens
Apr 4, 2008·Histochemistry and Cell Biology·Jens Waschke
Nov 17, 2010·The Journal of Biological Chemistry·Xuming MaoAimee S Payne
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Emmanuella DelvaAndrew P Kowalczyk
Aug 24, 2006·Journal of Translational Medicine·Alberta LuccheseDarja Kanduc
Feb 16, 2008·Journal of Autoimmune Diseases·Masha Fridkis-Hareli
Dec 4, 2009·Journal of Cell Science·Bhushan V DesaiKathleen J Green
Feb 6, 2014·PloS One·Sara N StahleyAndrew P Kowalczyk
May 1, 2010·Toxins·Michal BukowskiGrzegorz Dubin
Dec 21, 2012·Indian Journal of Dermatology, Venereology and Leprology·Divya SeshadriAmrinder J Kanwar
Aug 13, 2013·Autoimmune Diseases·Athanasios MavropoulosDimitrios P Bogdanos
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Nicola Cirillo, Stephen S Prime
Aug 2, 2007·Cell Communication & Adhesion·Tammy Sobolik-DelmaireJames K Wahl
Nov 15, 2006·Autoimmunity·Robert Gniadecki
Oct 10, 2012·Journal of the American Academy of Dermatology·Yael A LeshemDaniel Mimouni
Jun 20, 2008·The Journal of Investigative Dermatology·Rüdiger EmingMichael Hertl
Aug 22, 2014·The Journal of Investigative Dermatology·Christoph M HammersJohn R Stanley
Feb 13, 2008·The Journal of Investigative Dermatology·Eliane J MüllerMaja M Suter
Dec 30, 2006·The Journal of Investigative Dermatology·Tomomi E KimuraDavid R Garrod
Mar 30, 2007·The Journal of Investigative Dermatology·Aimee S PayneJohn R Stanley
Jan 19, 2006·The Journal of Investigative Dermatology·Michelle R MarquesLaura D Attardi
Oct 16, 2007·The Journal of Investigative Dermatology·Kathleen J Green, Cory L Simpson
Jul 21, 2007·The American Journal of Pathology·Volker SpindlerJens Waschke
Jun 19, 2007·Journal of Dermatological Science·Preety SharmaAimee S Payne
Nov 25, 2006·Gene Expression Patterns : GEP·Flavio RizzolioDaniela Toniolo
Jun 17, 2006·Journal of Cutaneous Pathology·Alessandro LanzaFernando Gombos
Jun 10, 2006·Experimental Dermatology·C M ChuongR Happle
Feb 21, 2006·Clinical and Experimental Dermatology·H FassihiJ E Mellerio
May 25, 2007·Journal of Cellular and Molecular Medicine·Sidonia Mihai, Cassian Sitaru
Jul 28, 2006·The EMBO Journal·Lina WilliamsonEliane J Müller
Oct 13, 2011·The Journal of Pathology·Matthew A BrookeDavid P Kelsell
Nov 22, 2011·International Journal of Dermatology·Christine J KoJennifer M McNiff
Sep 13, 2011·Clinical and Experimental Dermatology·M PanJ Zheng
Feb 26, 2011·IEEE Transactions on Nanobioscience·Carmen Kar Man FungAnimesh A Sinha
Oct 4, 2005·Journal of the American Academy of Dermatology·Jacob Mashiah, Sarah Brenner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of Cell Science
Margaret D KottkeAndrew P Kowalczyk
Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Masayuki Amagai
Proceedings of the National Academy of Sciences of the United States of America
Paula BerkowitzDavid S Rubenstein
© 2021 Meta ULC. All rights reserved