Destination shapes antibiotic resistance gene acquisitions, abundance increases, and diversity changes in Dutch travelers.

Genome Medicine
Alaric W D'SouzaJohn Penders

Abstract

Antimicrobial-resistant bacteria and their antimicrobial resistance (AMR) genes can spread by hitchhiking in human guts. International travel can exacerbate this public health threat when travelers acquire AMR genes endemic to their destinations and bring them back to their home countries. Prior studies have demonstrated travel-related acquisition of specific opportunistic pathogens and AMR genes, but the extent and magnitude of travel's effects on the gut resistome remain largely unknown. Using whole metagenomic shotgun sequencing, functional metagenomics, and Dirichlet multinomial mixture models, we investigated the abundance, diversity, function, resistome architecture, and context of AMR genes in the fecal microbiomes of 190 Dutch individuals, before and after travel to diverse international locations. Travel markedly increased the abundance and α-diversity of AMR genes in the travelers' gut resistome, and we determined that 56 unique AMR genes showed significant acquisition following international travel. These acquisition events were biased towards AMR genes with efflux, inactivation, and target replacement resistance mechanisms. Travel-induced shaping of the gut resistome had distinct correlations with geographical desti...Continue Reading

References

Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J F Acar
May 27, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E Cosgrove, Yehuda Carmeli
Jul 12, 2003·FEMS Microbiology Letters·T D LawleyL S Frost
Mar 9, 2005·Molecular Microbiology·Holly L HamiltonJoseph P Dillard
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew E Falagas, Sofia K Kasiakou
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E Cosgrove
Aug 26, 2006·The Lancet Infectious Diseases·Jian LiDavid L Paterson
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Feb 6, 2007·Nature Reviews. Microbiology·Gerard D Wright
Apr 11, 2008·Molecular Microbiology·Vladimir Pelicic
Aug 14, 2008·The Journal of Antimicrobial Chemotherapy·P M Hawkey
Dec 17, 2009·BMC Bioinformatics·Christiam CamachoThomas L Madden
Mar 10, 2010·BMC Bioinformatics·Doug HyattLoren J Hauser
Apr 27, 2010·Journal of Bacteriology·Alain Filloux
Jul 14, 2010·Bioinformatics·Lionel GuySiv G E Andersson
Sep 14, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K Kennedy, P Collignon
Feb 10, 2012·PloS One·Ian HolmesChristopher Quince
Apr 18, 2012·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Anton BankevichPavel A Pevzner
Jul 12, 2012·The Journal of Antimicrobial Chemotherapy·Ea ZankariMette Voldby Larsen
Sep 1, 2012·Science·Kevin J ForsbergGautam Dantas
Sep 8, 2012·Current Opinion in Microbiology·Gautam Dantas, Morten O A Sommer
Apr 10, 2013·Genome Research·Kristoffer ForslundPeer Bork
May 16, 2013·The Journal of Antimicrobial Chemotherapy·Ase Ostholm-BalkhedUNKNOWN Travel Study Group of Southeast Sweden
Jul 28, 2013·Emerging Infectious Diseases·Sunita PaltansingKarin Ellen Veldkamp
Nov 21, 2013·The Lancet Infectious Diseases·Ramanan LaxminarayanOtto Cars
Mar 20, 2014·Bioinformatics·Torsten Seemann
Mar 25, 2014·Emerging Infectious Diseases·Christian J H von WintersdorffPetra F G Wolffs
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Apr 30, 2014·Antimicrobial Agents and Chemotherapy·Alessandra CarattoliHenrik Hasman
May 3, 2014·BioMed Research International·Laurent DortetPatrice Nordmann
May 23, 2014·Nature·Kevin J ForsbergGautam Dantas
Nov 16, 2014·Bioinformatics·Baris E SuzekUNKNOWN UniProt Consortium
May 23, 2015·PloS One·Michael BaymRoy Kishony
Jun 27, 2015·Microbiome·Aimee M MooreGautam Dantas
Aug 1, 2015·Science Advances·Jose C ClementeM Gloria Dominguez-Bello
Sep 30, 2015·Nature Methods·Duy Tin TruongNicola Segata
Dec 20, 2015·PLoS Computational Biology·James KaminskiCurtis Huttenhower
Dec 30, 2015·The Lancet Infectious Diseases·Maris S ArcillaUNKNOWN COMBAT consortium
May 14, 2016·Nature·Erica C PehrssonGautam Dantas
May 26, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E A ReulandA P van Dam
Aug 31, 2016·Nature Microbiology·Molly K GibsonGautam Dantas

❮ Previous
Next ❯

Citations

Aug 8, 2021·The Science of the Total Environment·Shaqiu ZhangAnchun Cheng

❮ Previous
Next ❯

Software Mentioned

Resfinder
FastANI
ggpubr
Deconseq
py
Vegan
Prot
networkD3
BlastP
Resfams

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.