Destruction of IgG-sensitized erythrocytes by human blood monocytes: modulation of inhibition by IgG

British Journal of Haematology
A FleerC P Engelfriet

Abstract

The in vitro interaction between monocytes and erythrocytes sensitized with non-complement binding IgG antibodies (i.e. the Rh antibody anti-D:EAIgG anti-D) is completely inhibited by low concentrations of IgG (E.G. 30--100 microgram/ml). However, the interaction between monocytes and erythrocytes sensitized with IgG anti-A (EAIgG anti-A) is not inhibited by IgG. The findings presented in this paper indicate that this difference is probably due to the difference in the number of IgG antibody molecules per EAIgG. Thus, the higher the number of IgG antibody molecules per EAIgG, the less the interaction between EAIgG and monocytes is inhibited by IgG. A second factor which proved to have a strong influence on inhibition by IgG was the number of EAIgG per monocyte. When the number of EAIgG per monocyte was increased from 1 to 32, the percentage of inhibition by a fixed amount of IgG (50 microgram/ml) decreased significantly. This in vitro effect is only evident when relatively weakly sensitized erythrocytes are used and, in vivo, destruction of these weakly sensitized red cells (e.g. EAIgG anti-D) is confined to the spleen. Since a considerable haemoconcentration occurs in this organ, it is conceivable that a high EAIgG:macrophage ...Continue Reading

References

Aug 1, 1975·The Journal of Clinical Investigation·E J VictoriaS P Masouredis
Aug 1, 1975·European Journal of Immunology·W P ZeijlemakerV P Eijsvoogel
Jan 1, 1975·Journal of Immunological Methods·P BiberfieldJ Sjöquist
Jan 1, 1974·Scandinavian Journal of Immunology·G DorvalH Wigzell
May 1, 1967·Vox Sanguinis·J EconomidouB Gardner
Nov 1, 1962·Transfusion·S P MASOUREDIS
Nov 1, 1963·The Journal of Clinical Investigation·M CONSTANTOULAKISW DAMESHEK
Mar 1, 1964·Vox Sanguinis·N C HUGHES-JONESR TELFORD
Jul 1, 1965·British Journal of Haematology·P L MOLLISONE ROCHNA

❮ Previous
Next ❯

Citations

Aug 1, 1994·Annals of Hematology·A C Newland, M G Macey
Aug 1, 1981·Cryobiology·F W van der MeulenA E von dem Borne
Jan 1, 1981·Journal of Immunological Methods·M De BoerD Roos
Apr 24, 1980·The New England Journal of Medicine·A A Bom-van NoorloosC J Melief
Mar 1, 1995·Transfusion Medicine·S S Armstrong-FisherS J Urbaniak
Jul 1, 1986·British Journal of Haematology·A G HadleyH Chapel
Jan 1, 1988·Vox Sanguinis·J Bennebroek Gravenhorst
Apr 1, 1985·Immunological Investigations·C J van OssJ Michaeli
Nov 1, 1981·Clinical Immunology and Immunopathology·S SuzukiT Ofuji
Jan 1, 1983·Annals of the New York Academy of Sciences·C J van OssA W Neumann
Mar 1, 1987·The Australian and New Zealand Journal of Psychiatry·K Peace, G Mellsop
Jun 1, 1986·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·C ConchaG Aström
Jun 1, 1991·British Journal of Addiction·D C MathersS A Scott
May 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·P J DukeT R Barnes
Jan 1, 1988·The American Journal of Drug and Alcohol Abuse·M GalanterJ Ferman
Jan 1, 1984·Clinical and Laboratory Haematology·A Hadley, A M Holburn
Jan 1, 1981·Clinical and Laboratory Haematology·M G KoopmanC P Engelfriet
Jan 1, 1985·Critical Reviews in Oncology/hematology·R J Sokol, S Hewitt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.