PMID: 2487036Oct 1, 1989Paper

Destructive arthritis, rheumatoid factor, and HLA-DR4. Susceptibility versus severity, a case-control study

Arthritis and Rheumatism
A CalinP T Klouda

Abstract

In response to the continuing debate as to whether seronegative rheumatoid arthritis (RA) and seropositive RA are part of the same disease spectrum or are distinct disorders, we evaluated 720 patients with definite and classic RA, of whom 53 subjects had definite persistently seronegative destructive disease. For all but 1 seronegative RA patient, a seropositive RA case control was identified and matched for age, disease duration, degree of destruction on hand radiographs, and disease-modifying drug therapy. DR typing was undertaken on these 105 patients, together with scoring of hand radiographs. The frequency of DR4 was 69% in seropositive RA patients and 60% in seronegative RA patients (P = 0.22), versus 36% in 318 healthy controls (P = 0.008 and P = 0.007 versus seropositive and seronegative RA, respectively). Patients were matched and rematched with different controls in a series of subanalyses in order to make comparisons of hand radiograph scores. We found that HLA-DR4 was associated with destructive RA in both seropositive and seronegative RA patients. In general, DR4+ patients had more severe disease by radiologic criteria than did DR4- patients. Thus, HLA-DR4 may be an additive factor to the serologic status and may b...Continue Reading

References

Jan 1, 1979·The Journal of Clinical Investigation·P Stastny, C W Fink
Feb 1, 1988·The American Journal of Medicine·N J OlsenT Pincus
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P K GregersenJ Schwenzer
Jul 1, 1986·Tissue Antigens·C BrautbarE D Albert
Jan 1, 1987·Journal of Clinical Immunology·G T NepomB S Nepom
Mar 1, 1987·Annals of the Rheumatic Diseases·N J McHughJ Dagger
Jan 1, 1985·Rheumatology International·C A PapasteriadesH M Moutsopoulos
Jan 1, 1985·Annals of the Rheumatic Diseases·W MiehleM Bunge
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B S NepomJ A Hansen
Nov 14, 1981·British Medical Journal·J C WoodrowG Zaphiropoulos
Aug 1, 1982·Annals of the Rheumatic Diseases·B SchiffE Gazit
May 1, 1981·The American Journal of Medicine·A Calin, S H Marks

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Citations

Feb 1, 1997·Arthritis and Rheumatism·U WagnerR Wassmuth
Dec 4, 1998·Springer Seminars in Immunopathology·R Thomas
May 5, 2006·Rheumatology International·Ramiz Al-SwailemMohammad Tariq
Apr 1, 1989·Current Opinion in Immunology·G T Nepom
Jul 29, 2009·Nature Reviews. Rheumatology·Alla SkapenkoHendrik Schulze-Koops
Jun 18, 1998·Annals of the New York Academy of Sciences·A Conti, G J Maestroni
Aug 1, 1992·Annals of the Rheumatic Diseases·C M DeightonD J Walker
Jul 1, 1993·Annals of the Rheumatic Diseases·K A BokiH M Moutsopoulos
Jan 1, 1995·Annual Review of Medicine·G T Nepom
Dec 31, 1997·The Journal of Clinical Investigation·K P MacDonaldR Thomas
Apr 19, 2005·Arthritis Research & Therapy·Alla SkapenkoHendrik Schulze-Koops
Nov 26, 2008·Arthritis Research & Therapy·Maya H BuchPaul Emery
Jul 1, 1994·European Journal of Immunology·U BrunsbergR Holmdahl
Sep 6, 2003·Journal of Clinical Periodontology·F B MercadoP M Bartold
Feb 10, 1998·The American Journal of Medicine·G S Alarcón
Jun 1, 1994·Seminars in Arthritis and Rheumatism·A R Poole, P Dieppe
Dec 1, 1990·Baillière's Clinical Rheumatology·N Bellamy, W W Buchanan
Jan 29, 2002·Best Practice & Research. Clinical Rheumatology·H Schulze-Koops, J R Kalden
Oct 22, 2002·Expert Opinion on Biological Therapy·Hendrik Schulze-Koops, Alla Skapenko
Jan 1, 1993·Scandinavian Journal of Rheumatology·L PaimelaS Koskimies
Jan 1, 1994·Scandinavian Journal of Rheumatology·T NankiS Arai
Apr 21, 1999·Lancet·A Calin
Feb 1, 1992·Baillière's Clinical Rheumatology·F A Wollheim, K B Eberhardt
Mar 9, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·C SeidlJ P Kaltwasser
Oct 1, 1990·Arthritis and Rheumatism
May 3, 1990·The New England Journal of Medicine·E D Harris
Jun 1, 1994·Seminars in Arthritis and Rheumatism·D van Schaardenburg, F C Breedveld

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