PMID: 15241243Jul 9, 2004Paper

Destructive, granulating lesion in the temporal bone after elevated plasma homocysteine

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Per BondingKlaus Qvortrup

Abstract

This is a presentation of a seemingly new otolaryngologic disease. This study was conducted at a tertiary referral center. A 38-year-old healthy man developed left-sided sudden deafness with vertigo and temporary left facial palsy. A granulating and destructive lesion in the left temporal bone was discovered; repeated histologic examination only showed simple granulation tissue. After 6 months, a part of the bony cochlea was extruded. With approximately 8 months' delay and after the patient had had postoperative lung embolism, plasma homocysteine was found to be significantly elevated, a condition known as an independent risk factor for thromboembolic lesions. In the acquired form, it is most often caused by nutritional deficiency of vitamin B cofactors. Accordingly, the patient was treated with folic acid, which rapidly normalized plasma homocysteine. Subsequently, the granulation tissue in the temporal bone gradually disappeared, clinically and radiologically, and the lesion healed, obviously without cochlea function. Thromboembolic lesion in the left temporal bone, probably in the thin end artery a. labyrintina, i.e., an avascular osteonecrosis. During the latest years, an association between avascular osteonecrosis (most of...Continue Reading

References

Jan 1, 1992·Annual Review of Nutrition·S S KangM R Malinow
Dec 8, 1993·JAMA : the Journal of the American Medical Association·J SelhubI H Rosenberg
Aug 1, 1993·Clinical Otolaryngology and Allied Sciences·M S QuraishiF Breatnach
Apr 16, 1998·The New England Journal of Medicine·G N Welch, J Loscalzo
May 12, 2001·Clinical Orthopaedics and Related Research·C J GlueckP Wang
Nov 1, 2001·Archives of Otolaryngology--head & Neck Surgery·L R LustigG T Nager
Sep 28, 2002·The Laryngoscope·Dai TakagiSatoshi Fukuda
Aug 5, 2003·The American Journal of Emergency Medicine·Christopher C LeeRobert S Crupi

❮ Previous
Next ❯

Citations

Feb 16, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Per Bonding, Tomaas Ravn
May 3, 2011·The Journal of Chemical Physics·Andrés Aguado, Oleg Kostko
Oct 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Charles J GlueckPing Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
G N Welch, Joseph Loscalzo
Proceedings of the National Academy of Sciences of the United States of America
Martine Cohen-SalmonChristine Petit
Journal of Clinical Pathology
J B GIBSOND W NEILL
© 2022 Meta ULC. All rights reserved