Destructive thyroiditis presenting as thyrotoxicosis followed by hypothyroidism during lenvatinib therapy for hepatocellular carcinoma.

Clinical Journal of Gastroenterology
Maito SuohNorifumi Kawada

Abstract

Hypothyroidism is a common adverse event of lenvatinib therapy for hepatocellular carcinoma (HCC), whereas thyrotoxicosis has rarely been reported in clinical trials. A 74-year-old man complaining of abdominal pain was found to have liver tumors and paraaortic lymphadenopathy. The intrahepatic lesions were diagnosed as HCC by angiography and treated with transcatheter arterial chemoembolization. Although localized prostate cancer was discovered incidentally, the etiology of paraaortic lymphadenopathy was assumed to be metastatic HCC. Lenvatinib 12 mg/day was started when his thyroid function tests were almost normal but was interrupted because of thyrotoxicosis. The patient was negative for tested thyroid autoantibodies. Color Doppler ultrasonography detected reduced thyroid blood flow, suggesting destructive thyroiditis. Although he resumed lenvatinib at 8 mg/day once his serum level of free thyroxine normalized, thyrotoxicosis recurred. Subsequently, he suffered hypothyroidism, which exacerbated despite levothyroxine replacement. Lenvatinib was discontinued as it was ineffective against the paraaortic lymph node metastasis, and external-beam radiotherapy was performed. After the completion of radiotherapy, the thyroid dysfunc...Continue Reading

References

Jul 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S E Hughes
Jun 27, 2003·The New England Journal of Medicine·Elizabeth N PearceLewis E Braverman
Nov 27, 2004·Endocrinology·Rosanne St BernardShereen Ezzat
Sep 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Tomomi KambaDonald M McDonald
Feb 13, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·K V S Hari KumarKirtikumar D Modi
Apr 1, 2009·Nature Reviews. Clinical Oncology·Francesco TorinoGiampietro Gasparini
Jan 23, 2010·Nature Reviews. Cancer·Nicholas Turner, Richard Grose
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Sep 4, 2010·The Tohoku Journal of Experimental Medicine·Kanako SakuraiKatsumi Yoshida
Sep 17, 2010·Cancer·Manuela SchmidingerChristoph C Zielinski
Feb 1, 2011·Thyroid : Official Journal of the American Thyroid Association·Leni van DoornRobin P Peeters
Sep 29, 2012·Clinical Genitourinary Cancer·Julia ClemonsThomas W Flaig
Feb 13, 2013·Thyroid : Official Journal of the American Thyroid Association·Noriko Makita, Taroh Iiri
May 15, 2013·World Journal of Radiology·Ragab Hani DonkolSami Boughattas
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yunlong YangYihai Cao
Aug 16, 2016·Thyroid : Official Journal of the American Thyroid Association·Douglas S RossMartin A Walter
Oct 6, 2016·Journal of Gastroenterology·Kenji IkedaHiromitsu Kumada
Jun 3, 2017·The Journal of Clinical Endocrinology and Metabolism·Carolien M BeukhofRobin P Peeters
Apr 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jorge A MarreroJulie K Heimbach
Apr 10, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Aug 22, 2018·Annales d'endocrinologie·Delphine DruiPhilippe Caron
Sep 29, 2018·Expert Opinion on Drug Safety·Masafumi IkedaShuichi Kaneko
May 31, 2019·Endocrine Journal·Yohei KoizumiYoichi Hiasa
Oct 30, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Toshifumi TadaYoichi Hiasa
Nov 25, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takeshi HatanakaToshio Uraoka

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Citations

Jan 22, 2021·Seminars in Cancer Biology·Alessio BasoloFerruccio Santini

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