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Desulfuration of 2-thiouridine with hydrogen peroxide in the physiological pH range 6.6-7.6 is pH-dependent and results in two distinct products

Bioorganic & Medicinal Chemistry Letters

Sep 26, 2013

Elzbieta SochackaBarbara Nawrot

Abstract

The 2-thiomodified nucleosides, located at first position of tRNAs anticodon, may constitute a primary target for oxidative attack under conditions of oxidative stress. Desulfuration of 2-thiouridine (S2U) was investigated in the (1)H NMR scale in the presence of 100mM H2O2 and phosphat...read more

Mentioned in this Paper

Biochemical Pathway
In Vivo NMR Spectroscopy
Phosphate buffers
Hydrogen Peroxide
MT-TA gene
Sulfur
Triplet Codon-amino Acid Adaptor Activity
Oxidative Stress
Oxidative Stress Analysis
Transfer RNA
Paper Details
References

Desulfuration of 2-thiouridine with hydrogen peroxide in the physiological pH range 6.6-7.6 is pH-dependent and results in two distinct products

Bioorganic & Medicinal Chemistry Letters

Sep 26, 2013

Elzbieta SochackaBarbara Nawrot

PMID: 24064499

DOI: 10.1016/j.bmcl.2013.08.114

Abstract

The 2-thiomodified nucleosides, located at first position of tRNAs anticodon, may constitute a primary target for oxidative attack under conditions of oxidative stress. Desulfuration of 2-thiouridine (S2U) was investigated in the (1)H NMR scale in the presence of 100mM H2O2 and phosphat...read more

Mentioned in this Paper

Biochemical Pathway
In Vivo NMR Spectroscopy
Phosphate buffers
Hydrogen Peroxide
MT-TA gene
Sulfur
Triplet Codon-amino Acid Adaptor Activity
Oxidative Stress
Oxidative Stress Analysis
Transfer RNA

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Paper Details
References
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