Desymmetrization of Achiral Heterobicyclic Alkenes through Catalytic Asymmetric Hydrophosphination

Chemistry, an Asian Journal
Abdul SadeerPak-Hing Leung

Abstract

Asymmetric addition of diarylphosphines to oxa- and azabicyclic alkenes proceeded in the presence of a chiral phosphapalladacycle catalyst and a mild acid at room temperature to give exclusively the enantioenriched addition products in excellent yields and good selectivities. Three new chiral carbon centers were generated stereoselectively by the catalytic hydrophosphination reaction.

References

Jan 22, 2003·Accounts of Chemical Research·Mark LautensSheldon Hiebert
Feb 5, 2004·Journal of the American Chemical Society·Mark Lautens, Sheldon Hiebert
Apr 3, 2004·The Journal of Organic Chemistry·Paul Leong, Mark Lautens
Jan 14, 2005·Organic Letters·Ramón Gómez ArrayásJuan C Carretero
May 25, 2006·Journal of the American Chemical Society·Yong-hwan ChoMark Lautens
Jun 27, 2007·Accounts of Chemical Research·Dinesh Kumar Rayabarapu, Chien-Hong Cheng
May 16, 2008·Journal of the American Chemical Society·Ryan A ShenviPhil S Baran
Jan 27, 2009·Bioorganic & Medicinal Chemistry Letters·Chris DockendorffMirosław J Tomaszewski
May 15, 2009·Chemical Reviews·Denise A ColbyJonathan A Ellman
Apr 3, 2010·Journal of the American Chemical Society·Jian-Jun FengWei-Liang Duan
Oct 15, 2010·The Journal of Organic Chemistry·Yuhua LongYu Chen
Dec 15, 2010·Angewandte Chemie·Shingo ItoMasaharu Nakamura
May 12, 2012·Chemical Communications : Chem Comm·Takahiro SawanoTamio Hayashi
Dec 12, 2012·Organic & Biomolecular Chemistry·Jun HuAlbert S C Chan
Jun 19, 2013·Organic & Biomolecular Chemistry·Dingqiao YangChunrong Li
Sep 17, 2013·Chemical Communications : Chem Comm·Renshi LuoAlbert S C Chan
Nov 28, 2013·The Journal of Organic Chemistry·Xuejing PanDingqiao Yang
Feb 20, 2014·Organic & Biomolecular Chemistry·Dingqiao Yang, Ni Liang
May 16, 2014·The Journal of Organic Chemistry·Zhongyi ZengWen Zhou
Jul 6, 2014·Beilstein Journal of Organic Chemistry·Iris WautersChristian V Stevens
Feb 14, 2015·The Journal of Organic Chemistry·Ling MengDingqiao Yang
Jul 17, 2015·Organic & Biomolecular Chemistry·Chaoyuan ZengBaomin Fan
Aug 4, 2015·Chemical Communications : Chem Comm·Midori Nagamoto, Takahiro Nishimura
Aug 20, 2015·ACS Medicinal Chemistry Letters·Aaron BalogMark E Salvati

❮ Previous
Next ❯

Citations

Feb 6, 2021·Chemical Society Reviews·Sundaravel Vivek KumarPatrick J Guiry
Jan 7, 2021·Current Organic Synthesis·Austin PounderWilliam Tam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.