Desynchronized respiratory rhythms and their interactions in cats with split brain stems

The Journal of Physiology
F L Eldridge, D Paydarfar

Abstract

1. The effects on activities and rhythms of the two opposing phrenic nerves (C5 roots) of mid-line sagittal splitting of the medulla were determined in anaesthetized or decorticate, vagotomized, paralysed and ventilated cats. 2. Splitting the medulla above the obex led to marked decreases of phrenic activity on both sides, but no desynchronization of the two phrenic rhythms occurred. Further splitting to more than 3 mm below the obex led to desynchronized phrenic rhythms in fourteen of the fifteen animals that survived the necessary surgery, although it was often necessary to increase respiratory drive by means of hypercapnia, stimulatory drugs or electrical stimulation of the mesencephalon to cause the rhythms to occur. 3. When only the brain stem had been split, the two desynchronized rhythms showed interactions that led to modulations of amplitude of phrenic bursts, both being larger when in phase than when out of phase. In addition each side modulated the rhythm of the opposite side, demonstrating a 'magnet' effect. 4. Both types of modulation were eliminated after additional splitting of the spinal cord at the level (C5-C6) of the phrenic motoneurone pools. 5. Potential explanations for the amplitude modulations include cr...Continue Reading

Citations

Jun 24, 1998·Neuroscience Letters·J H PeeverJ Duffin
Sep 9, 2008·Respiratory Physiology & Neurobiology·David J MajewskiStephen M Johnson
Mar 25, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Rujuta ParlikarGanesan Venkatasubramanian
Jul 18, 2008·Journal of Neurophysiology·Lauren S SegersBruce G Lindsey

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