Detachment of low-force bridges contributes to the rapid tension transients of skinned rabbit skeletal muscle fibres

The Journal of Physiology
C Y SeowL E Ford

Abstract

1. To probe the cross-bridge cycle and to learn more about the cardioplegic agent BDM (2,3-butanedione monoxime), its effects on the force-velocity properties and tension transients of skinned rabbit muscle fibres were studied at 1-2 degrees C and pH 7.0. 2. Three millimolar BDM decreased isometric force by 50%, velocity by 29%, maximum power by 73%, and stiffness by 25%, so that the relative stiffness (stiffness/force ratio) increased by 50% compared with reference conditions in the absence of BDM. 3. Tension transients obtained under the reference condition (0 BDM) could be represented by three components whose instantaneous stiffness accounted for the initial (Phase 1) force deviation and whose exponential recoveries caused the rapid, partial (Phase 2) force recovery following the step. The fastest component had non-linear extension-force properties that accounted for about half the isometric stiffness and it recovered fully. The two slower components had linear extension-force properties that together accounted for the other half of the sarcomere stiffness. These components recovered only partially following the step, producing the intermediate (T2) level which the force approached during Phase 2. 4. Matching the force tran...Continue Reading

References

Oct 1, 1992·Journal of Muscle Research and Cell Motility·M A BagniP Garzella
Jun 1, 1992·Journal of Muscle Research and Cell Motility·C Y Seow, L E Ford
Dec 1, 1990·The Journal of Physiology·V Lombardi, G Piazzesi
Apr 1, 1990·Pflügers Archiv : European journal of physiology·E M BlanchardN R Alpert
Apr 1, 1988·Journal of Muscle Research and Cell Motility·K HoriutiS Kurihara
Jan 1, 1988·Pflügers Archiv : European journal of physiology·M W FryerG D Lamb
Jun 1, 1988·Biophysical Journal·P B Chase, M J Kushmerick
May 1, 1988·The American Journal of Physiology·R E Godt, D W Maughan
Sep 1, 1986·The Journal of Physiology·Y E Goldman, R M Simmons
Feb 27, 1973·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A F Huxley
Oct 22, 1971·Nature·A F Huxley, R M Simmons
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B BrennerE Eisenberg
Feb 1, 1981·The Journal of Physiology·L E FordR M Simmons
Nov 1, 1982·The American Journal of Physiology·Y L ChiuL E Ford
Sep 1, 1959·British Journal of Pharmacology and Chemotherapy·H EDERY
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A V HILL

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Citations

Oct 3, 2009·Pflügers Archiv : European journal of physiology·Julien OchalaLars Larsson
Apr 25, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Julien OchalaLisa S Krivickas
Apr 1, 2005·Proceedings. Biological Sciences·Dilson E Rassier, Walter Herzog
Jul 31, 2008·Proceedings. Biological Sciences·Dilson E Rassier
Nov 20, 2002·Annals of the New York Academy of Sciences·Sergio D RoséJosé-María Trifaró
Sep 29, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nima AlamdariPer-Olof Hasselgren
Jan 5, 2010·Journal of Theoretical Biology·Michael Günther, Syn Schmitt
Jun 15, 2004·Journal of Applied Physiology·Dilson E Rassier, Walter Herzog
Nov 30, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rizwan QaisarLars Larsson
Jul 9, 2005·Journal of Applied Physiology·Dilson E Rassier, Walter Herzog
Jun 5, 1998·The American Journal of Physiology·C Y SeowB H Bressler
Jun 27, 2018·International Journal of Molecular Sciences·Alf MånssonDilson E Rassier
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R C Scaduto, L W Grotyohann

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