Abstract
One of the most striking characteristics of nasopharyngeal carcinoma (NPC) is the presence of a very abundant immune cells infiltrate containing mainly T-lymphocytes. The purpose of this study was to present our analysis providing a comprehensive characterization of antitumor inflammatory response in NPC. The densities of 9 types of inflammatory cells were assessed in 197 patients with NPC, including CD3 + T-lymphocytes, CD8 + cytotoxic T-lymphocytes, CD20 + B-lymphocytes, CD56 + natural killer (NK) cells, FOXP3 + regulatory T-lymphocytes, CD1a + immature dendritic cells, CD83 + mature dendritic cells, neutrophil elastase + neutrophils, and tryptase + mast cells. We characterized the inflammatory infiltrate in relation to clinical stage and patient survival. The expression of programmed death-1 (PD-1) on tumor-infiltrating lymphocytes (TILs) was also detected. The correlations between PD-1 expression and clinical characteristics and posttreatment outcome were analyzed. The patients with NPC with a low density of tumor-infiltrating FOXP3+, CD8 + T-lymphocytes, neutrophils, and mast cells showed a significantly longer overall survival (OS) and progression-free survival (PFS). However, patients with a high density of NK cells show...Continue Reading
References
Feb 1, 1987·British Journal of Cancer·P HeraitT Tursz
Feb 1, 1996·Cancer·S E LeightonC A van Hasselt
Nov 16, 2002·The Journal of Pathology·Joost J OudejansChris J L M Meijer
Jun 14, 2005·Lancet·William I Wei, Jonathan S T Sham
Mar 25, 2006·Nature Reviews. Immunology·Weiping Zou
Jun 30, 2006·Cancer Science·Ying ZhengBo-Jian Zheng
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gaynor J BatesAlison H Banham
Jan 31, 2007·British Journal of Cancer·K-M LauM H L Ng
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sameer A SiddiquiEugene D Kwon
Jul 25, 2007·Journal of Gastroenterology and Hepatology·Maya Gulubova, Tatyana Vlaykova
Sep 13, 2007·British Journal of Cancer·N NonomuraA Okuyama
Nov 8, 2007·PloS One·Jiang LiMaria G Masucci
Oct 7, 2008·Oncogene·I Waldhauer, A Steinle
Feb 18, 2009·Clinical and Experimental Immunology·W K YipH F Seow
Jan 13, 2010·Molecular Cancer·Yi-Lan ZhangYi-Xin Zeng
Jul 27, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mei-Chi HsuYao Chang
Jan 27, 2011·Cancer Metastasis Reviews·Jing LiuBo Huang
Oct 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David Z ChangPatrick Hwu
Jan 18, 2012·Seminars in Cancer Biology·Claire GourzonesPierre Busson
Mar 16, 2012·Nature Reviews. Cancer·Wolf Herman FridmanJérôme Galon
Apr 25, 2012·Virchows Archiv : an International Journal of Pathology·Juha P VäyrynenMarkus J Mäkinen
Jun 14, 2013·Journal of Translational Medicine·Maria Libera AsciertoMasoud H Manjili
Aug 30, 2013·Science Translational Medicine·Stefani SprangerThomas F Gajewski
Feb 24, 2015·Medical Oncology·Jianwei ZhangLi Zhang
Nov 3, 2016·The New England Journal of Medicine·Vassiliki A Boussiotis
Dec 8, 2016·The Lancet Oncology·Geoffrey T GibneyMichael B Atkins
Mar 4, 2017·Scientific Reports·Yajuan ZhouConghua Xie
Apr 6, 2017·Oncotarget·Yanyan TangZhaoyang Zeng
Citations
Jul 18, 2019·Cancer Immunology, Immunotherapy : CII·Anna MakowskaUdo Kontny
Jul 31, 2019·Expert Opinion on Biological Therapy·James Ch ChowWilliam Cs Cho
Mar 20, 2020·American Society of Clinical Oncology Educational Book·Brigette B Y MaJun Ma
Apr 7, 2020·Expert Opinion on Therapeutic Targets·Valentin BalochePierre Busson
Apr 19, 2020·Cancer Science·Susumu SuzukiToyonori Tsuzuki
Jun 24, 2020·Cancer Medicine·Jie WangXiangping Li
Apr 14, 2018·Pathogens·Geok Wee TanArjan Diepstra
Oct 30, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Hui XuLijun Lu
May 30, 2019·Cancer Cell International·Zi-Lu HuangYun-Fei Xia
Jul 28, 2020·Frontiers in Immunology·Shuo ZhangZengwu Shao
Jul 28, 2020·Cancers·Mingdan DengMaria Li Lung
Aug 2, 2020·Cancer Immunology, Immunotherapy : CII·Anna MakowskaUdo Kontny
Dec 26, 2018·Head & Neck·Caineng CaoXiaozhong Chen
Jun 1, 2020·Journal of Cancer Research and Therapeutics·Wei SunWeiping Wen
Apr 2, 2020·Virchows Archiv : an International Journal of Pathology·Yuanyuan ZhaoMulan Jin
Mar 23, 2020·BMC Cancer·Nasser Al-RajhiHazem Ghebeh
Jan 26, 2021·Frontiers in Oncology·Xiaoxia JiaJiafu Ji
Jun 18, 2020·European Journal of Immunology·Soumya PanigrahiScott F Sieg
Oct 30, 2020·Frontiers in Oncology·Yuri UedaMakoto Tahara
Jan 12, 2021·Journal for Immunotherapy of Cancer·Andrew J CharapAmir Horowitz
Jan 18, 2021·Oral Oncology·David Johnson, Brigette B Y Ma
Nov 14, 2020·Translational Oncology·Sarah NersesianJeanette E Boudreau
Mar 23, 2021·Nature Communications·Lanqi GongXin-Yuan Guan
May 25, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Weixing LiuXiaowen Zhang
Aug 1, 2021·EBioMedicine·Yasuhiro MaruokaHisataka Kobayashi
Jul 30, 2021·Technology in Cancer Research & Treatment·Birhanu Aberha BereleGuifang Yang
Aug 12, 2021·Genome Medicine·Emily F Davis-MarcisakElana J Fertig