Detailed analysis of leucokinin-expressing neurons and their candidate functions in the Drosophila nervous system

Cell and Tissue Research
María de HaroPilar Herrero

Abstract

The distribution of leucokinin (LK) neurons in the central nervous system (CNS) of Drosophila melanogaster was described by immunolabelling many years ago. However, no detailed underlying information of the input or output connections of their neurites was then available. Here, we provide a more accurate morphological description by employing a novel LK-specific GAL4 line that recapitulates LK expression. In order to analyse the possible afferent and efferent neural candidates of LK neurons, we used this lk-GAL4 line together with other CNS-Gal4 lines, combined with antisera against various neuropeptides or neurotransmitters. We found four kinds of LK neurons in the brain. (1) The lateral horn neurons connect the antennal glomerula to the mushroom bodies. (2) The suboesophageal neurons connect the gustatory receptors to the suboesophageal ganglia and ventral nerve cord. (3) The anterior neurons innervate the corpus cardiacum of the ring gland but LK expression is surprisingly not detectable from the third instar onwards in these neurons. (4) A set of abdominal ganglion neurons connect to the dorsal median tract in larvae and send their axons to a segmental muscle 8. Thus, the methods employed in our study can be used to identif...Continue Reading

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Citations

Mar 2, 2016·Nature Neuroscience·Matthieu CaveyJustin Blau
Oct 25, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Pilar HerreroFernando J Diaz-Benjumea
Mar 30, 2016·Current Biology : CB·Kazuma MurakamiAlex C Keene
Mar 30, 2016·Nature Neuroscience·Matthieu Flourakis, Ravi Allada
May 25, 2010·Current Biology : CB·Bader Al-AnziSeymour Benzer
Jun 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hyeogsun KwonPatricia V Pietrantonio
Aug 11, 2016·The Journal of Comparative Neurology·Javier Alvarez-RiveroPilar Herrero
Mar 28, 2019·Open Biology·Suewei LinChang-Hui Tsao
Feb 2, 2018·Proceedings of the National Academy of Sciences of the United States of America·Do-Hyoung KimMichael E Adams
Aug 23, 2020·Cell and Tissue Research·Dick R Nässel, Meet Zandawala
Aug 10, 2020·Nature Communications·Chenxi LiuWei Zhang
Nov 23, 2016·ELife·Keith R MurphyWilliam W Ja
Oct 12, 2018·Journal of Neurogenetics·Kiel G OrmerodA Joffre Mercier
Oct 30, 2019·Nature Neuroscience·Bhagyashree SenapatiSuewei Lin
Feb 7, 2021·International Journal of Molecular Sciences·Dick R Nässel, Shun-Fan Wu
Mar 7, 2021·International Journal of Molecular Sciences·Dick R Nässel
Mar 31, 2021·Proceedings of the National Academy of Sciences of the United States of America·Gabriel T KoremanChun Han
May 2, 2013·Development·Alicia Estacio-GómezFernando J Díaz-Benjumea

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