PMID: 7515659Mar 1, 1994Paper

Detailed analysis of loss of heterozygosity on chromosome band 17p13 in breast carcinoma on the basis of a high-resolution physical map with 29 markers

Genes, Chromosomes & Cancer
M IsomuraY Nakamura

Abstract

We have constructed a physical map of chromosome band 17p13, using 29 markers that had been localized to 17p13 by means of fluorescence in situ hybridization (FISH) and analysis by pulsed-field gel electrophoresis (PFGE). The map spans nearly 8 Mb of genomic DNA, and the estimated average distance between each marker is roughly 290 kb. The p13 band of chromosome 17 is thought to contain a putative tumor suppressor gene in addition and distal to TP53. Deletion mapping in a large number of breast carcinomas indicated that the tumor suppressor gene lies between the loci defined by cC117-708 (D17S878) and p144D6 (D17S34), which are an estimated 7 Mb apart. Our results should contribute to construction of a contig map of chromosome band 17p13 with cosmid and/or YAC (yeast artificial chromosome) clones, and to isolation of the putative tumor suppressor gene.

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Citations

Oct 23, 1997·Genes, Chromosomes & Cancer·J S MorrisP A Edwards
Sep 17, 1998·Genes, Chromosomes & Cancer·J BernardinoB Dutrillaux
Dec 1, 1995·Genes, Chromosomes & Cancer·I Bièche, R Lidereau
Sep 22, 2001·Cancer Genetics and Cytogenetics·C HoffA Poustka
Nov 5, 2002·Critical Reviews in Oncology/hematology·F Lerebours, R Lidereau
Feb 19, 2002·Journal of the American College of Surgeons·S Eva Singletary
Aug 17, 1999·Seminars in Cancer Biology·S Ingvarsson
Jun 30, 2000·Japanese Journal of Cancer Research : Gann·E TsuchiyaK Nakagawa

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