Detailed contact data and the dissemination of Staphylococcus aureus in hospitals

PLoS Computational Biology
Thomas ObadiaI-Bird Study Group

Abstract

Close proximity interactions (CPIs) measured by wireless electronic devices are increasingly used in epidemiological models. However, no evidence supports that electronically collected CPIs inform on the contacts leading to transmission. Here, we analyzed Staphylococcus aureus carriage and CPIs recorded simultaneously in a long-term care facility for 4 months in 329 patients and 261 healthcare workers to test this hypothesis. In the broad diversity of isolated S. aureus strains, 173 transmission events were observed between participants. The joint analysis of carriage and CPIs showed that CPI paths linking incident cases to other individuals carrying the same strain (i.e. possible infectors) had fewer intermediaries than predicted by chance (P < 0.001), a feature that simulations showed to be the signature of transmission along CPIs. Additional analyses revealed a higher dissemination risk between patients via healthcare workers than via other patients. In conclusion, S. aureus transmission was consistent with contacts defined by electronically collected CPIs, illustrating their potential as a tool to control hospital-acquired infections and help direct surveillance.

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Citations

Feb 24, 2016·Computational and Mathematical Methods in Medicine·Leilei QuMingfeng He
Apr 22, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Thomas ObadiaDidier Guillemot
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Mar 19, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·J LegrandD Guillemot
May 22, 2019·PLoS Computational Biology·Francesco PinottiChiara Poletto
Jun 25, 2016·PLoS Computational Biology·Rossana Mastrandrea, Alain Barrat
Aug 5, 2017·PLoS Computational Biology·Tjibbe DonkerJulie V Robotham
Oct 1, 2016·Antimicrobial Resistance and Infection Control·Nataliya G BatinaDörte Döpfer
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Apr 3, 2021·Scientific Reports·Eugenio ValdanoVittoria Colizza
Aug 27, 2021·PLoS Computational Biology·Simon MaurasLaurent Viennot

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