PMID: 9421353Jan 8, 1998Paper

Detailed deletion mapping at chromosome 9p21 in non-small cell lung cancer by microsatellite analysis and fluorescence in situ hybridization

International Journal of Cancer. Journal International Du Cancer
K OkamiJ Jen

Abstract

We examined 82 cases of primary non-small cell lung cancer (NSCLC) for loss of heterozygosity (LOH) at the chromosome 9p21-24 region using 16 microsatellite markers. A total of 52 tumors (63%) displayed LOH, and 25 of these cases displayed LOH for all markers. Two cases had small hemizygous losses confined to the p16 gene and more distal markers, whereas 3 cases had loss proximal to p16 and extended through marker D9S126. This latter region has recently been described as another minimal region of loss at 9p21 in lung cancer. However, homozygous deletion of the p16 gene was observed in 18 of 85 cases, with only 5 cases having large deletions extended into the D9S126 region. Furthermore, we did not observe homozygous deletion at the 9p21 region that excluded the p16 gene. Fluorescence in situ hybridization (FISH) analysis using genomic probes spanning either the p16 or Hel-N1 (located at D9S126) gene was performed in 14 tumors. The results from FISH correlated with the chromosomal mapping data, suggesting that the p16 region is the major target of deletion at chromosome 9p21 in primary NSCLC.

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Citations

May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·K HibiD Sidransky
Feb 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rafael SireraCarlos Camps
Mar 10, 2001·Experimental Cell Research·J W Rocco, D Sidransky
Jul 11, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kazuya KondoAkira Tangoku
Apr 6, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C F EisenbergerW T Knoefel
Nov 6, 2002·Japanese Journal of Cancer Research : Gann·Naoki YanagawaTeiichi Motoyama
Sep 25, 1999·International Journal of Cancer. Journal International Du Cancer·M PartridgeJ Langdon
Jan 7, 2017·The International Journal of Biological Markers·Érika Aparecida Felix de BarrosMiguel Srougi
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Jung-Ta ChenYi-Ching Wang
Sep 29, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·W HilbeE Wöll
May 8, 2000·International Journal of Cancer. Journal International Du Cancer·K YamaguchiJ Jen
Oct 16, 1999·International Journal of Cancer. Journal International Du Cancer·G PerincheryR Dahiya
Dec 6, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takeshi YoshikawalAtsushi Ochiai

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