Detailed deposition analysis of inertial and diffusive particles in a rat nasal passage

Inhalation Toxicology
Jingliang DongJi Yuan Tu

Abstract

Rats have been widely used as surrogates for evaluating the health effects of inhaled airborne particulate matter. To provide a thorough understanding of particle transport and deposition mechanisms in the rat nasal airway, this article presents a computational fluid dynamics (CFD) study of particle exposure in a realistic rat nasal passage under a resting flow condition. Particles covering a diameter range from 1 nm to 4 µm were passively released in front of the rat's breathing zone, and the Lagrangian particle tracking approach was used to calculate individual particle trajectories. Detailed particle deposition analysis shows the deposition of inertial particles >2 µm is high in the rat nasal vestibule and more than 70% of all inhaled inertial particles were trapped in this region. While for diffusive nanoparticles, the vestibule filtration effect is reduced, only less than 60% of inhaled nanoparticles were blocked by the anterior nasal structures. The particle exposure in the olfactory region only shows notable deposition for diffusive nanoparticles, which peaks at 9.4% for 5 nm particles. Despite the olfactory deposition remains at a low level, the ratio between the olfactory and the main passage is kept around 30-40% for ...Continue Reading

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Citations

Sep 18, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Reza TabeGoodarz Ahmadi
Aug 23, 2019·Inhalation Toxicology·Ya ZhangGuoxi Zheng
Nov 19, 2020·International Journal for Numerical Methods in Biomedical Engineering·Jingliang DongJiyuan Tu
Dec 28, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Robert A Yokel

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