Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma

Cytogenetics and Cell Genetics
S BekriP Gaudray

Abstract

Amplification of loci present on band q13 of human chromosome 11 is a feature of a subset of estrogen receptor positive breast carcinomas prone to metastasis. As many as five distinct amplification units have been described on 11q13. They include particularly a genomic area encompassing the GARP gene at 11q13.5-->q14.1. We have reassessed our current knowledge of this region, located telomeric to CCND1 and EMS1, which is amplified in 7-10% of mammary tumors. The loose definition of the driving forces of these amplification events led us to map accurately the boundaries of the amplifiable region, and thus to contribute a physical and transcriptional map of a 3-Mb region of chromosome 11. Four new genes were placed on the regional map, namely CBP2, CLNS1A, UVRAG, and PAK1. We have narrowed the core of the 11q13-->q14 amplicon to a 350-kb area encompassing D11S533, mostly on its telomeric side. The map reported here represents an indispensable step toward sequencing the entire region, and thus toward uncovering gene(s) which play(s) a critical role in breast cancer progression.

Citations

Jan 28, 2009·Apoptosis : an International Journal on Programmed Cell Death·Avital Eisenberg-Lerner, Adi Kimchi
Jul 29, 2009·Breast Cancer Research and Treatment·Lindsay A BrownDavid G Huntsman
Feb 21, 2008·Cancer Metastasis Reviews·Gordon ChanBenjamin G Neel
Jan 24, 2009·Cancer Metastasis Reviews·Bettina DummlerJeffrey Field
Jul 25, 2008·Journal of Mammary Gland Biology and Neoplasia·Richard Marcotte, William J Muller
Nov 7, 2000·Cancer Genetics and Cytogenetics·J P ParkT K Mohandas
Jun 20, 2002·Cancer Genetics and Cytogenetics·Jian Ming WenXin Yuan Guan
May 21, 2003·Breast Cancer Research and Treatment·Christopher J OrmandyRobert L Sutherland
Mar 28, 2009·Cell Death and Differentiation·A Eisenberg-LernerA Kimchi
Aug 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dat Q TranEthan M Shevach
Aug 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Xin HuangTony E Godfrey
Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·B A CunninghamW B Kinlaw
Aug 9, 2012·Molecular Cancer Research : MCR·Sarah J AdamsJulide T Celebi
Aug 21, 2004·Breast Cancer Research : BCR·Jun Yao, Kornelia Polyak
Jan 12, 2005·Breast Cancer Research : BCR·Anupama E GururajRakesh Kumar
Jul 2, 2011·Molecular Endocrinology·Jing TaoMaria Diakonova
Sep 9, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Manuel Hidalgo PascualReposo Ramirez-Lorca
Oct 5, 2011·Critical Reviews in Eukaryotic Gene Expression·Che-Pei KungMaureen Murphy
May 10, 2011·International Journal of Biological Sciences·Xiu-Li XuJun-Wen Li
Dec 7, 2013·Breast Cancer Research and Treatment·Yanhong LiuMelissa L Bondy
May 8, 2008·The British Journal of Dermatology·X Mao, G Orchard
Aug 21, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Carmen Chak-Lui WongIrene Oi-Lin Ng
Mar 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jing HouGong Yang
Nov 20, 2012·Cellular Logistics·Diana Zi Ye, Jeffrey Field
Aug 8, 2014·Frontiers in Genetics·Jason T ServissDan Grandér
Apr 4, 2009·The American Journal of Pathology·Basil HorstJulide Tok Celebi
Mar 1, 2014·The Journal of Surgical Research·Hongwei ChenHongying Qiao
Jul 20, 2005·Neoplasia : an International Journal for Oncology Research·Raymond E MenardRaymond R Mattingly
Oct 3, 2006·Cancer Genetics and Cytogenetics·Adán ValladaresDiego J Arenas Aranda
Jan 26, 2005·Journal of Dental Research·S C Reshmi, S M Gollin
Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·C De JuanM Benito
Jun 27, 2006·Nature Cell Biology·Chengyu LiangJae U Jung
Dec 22, 2005·Nature Medicine·Mohamed Bentires-AljHaihua Gu
Nov 26, 2002·International Journal of Cancer. Journal International Du Cancer·Johannes W G JanssenCharles Theillet

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