Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3

Human Molecular Genetics
M StackJ Heighway

Abstract

The chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FISH) experiments, using isolated yeast artificial chromosomes (YACs) and cosmids. Eight polymorphic markers ordered within this new physical map and one external marker were used to investigate the pattern of loss of heterozygosity in a panel of 40 sporadic breast tumour patients. The data revealed a region of high loss (60%) within distal 17p13.3, defined by markers D17S926, D17S695 and D17S849 which mapped close together. A contig of YACs was constructed physically linking these three markers.

Citations

Oct 23, 1997·Genes, Chromosomes & Cancer·J S MorrisP A Edwards
Sep 22, 2001·Cancer Genetics and Cytogenetics·C HoffA Poustka
Nov 5, 2002·Critical Reviews in Oncology/hematology·F Lerebours, R Lidereau
May 21, 2003·Breast Cancer Research and Treatment·Peter O'Connell
May 17, 2000·The Journal of Experimental Medicine·J JankeS Scherneck
Nov 8, 2008·Journal of Pediatric Hematology/oncology·David R CzuchlewskiQian-Yun Zhang
Apr 21, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L L HansenT A Kruse
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·R LucitoM Wigler
Dec 24, 2015·International Journal of Molecular Sciences·Hun Seok LeeYoung Kee Shin
Apr 20, 2005·Cancer Letters·Paola ParrellaVito Michele Fazio
Aug 17, 1999·Seminars in Cancer Biology·S Ingvarsson
Dec 31, 1997·Genes, Chromosomes & Cancer·S J PlummerG Casey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.