Detailed process of bone remodeling after achievement of osseointegration in a rat implantation model

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Maiko HagaTakeyasu Maeda

Abstract

Osseointegration is regarded as the most appropriate implant-bone interface in dental implantation. However, damaged bone with empty osteocytic lacunae driven by implant cavity preparation remains even after the completion of osseointegration. Although previous studies have suggested the occurrence of bone remodeling around implants, information on its detailed process is meager. Our study aimed to examine the fate of bone around titanium implants after the establishment of osseointegration on an animal model using the rat maxilla. Titanium implants were inserted into prepared bone cavities of the rat maxilla. Bone formation and maturation processes were evaluated by double staining for alkaline phosphatase and tartrate-resistant acid phosphatase, immunohistochemistry for bone matrix proteins, vital staining with calcein, and elemental mapping with an electron probe microanalyzer. Bone with empty osteocytic lacunae or pyknosis remained between the intact preexisting and newly formed woven bones at post 1 month. It gradually decreased to disappear completely by active bone remodeling with a synchronized coordination of alkaline phosphatase-positive osteoblasts and tartrate-resistant acid phosphatase-reactive osteoclasts at post ...Continue Reading

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Citations

May 4, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Maiko HagaTakeyasu Maeda
Oct 26, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Naroa Lozano-CarrascalJosé Luis Calvo-Guirado
Oct 16, 2015·Acta Cirúrgica Brasileira·Carlos Rodrigo Barros de SiqueiraAlex Semenoff Segundo
May 3, 2013·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Anand DusadEdward V Fehringer
Dec 24, 2018·Journal of Biomedical Materials Research. Part a·Yoko TakemuraKiyoshi Koyano
Nov 9, 2016·The Journal of Advanced Prosthodontics·Re-Mee DohMoon-Kyu Chung
Oct 31, 2018·Clinical Oral Investigations·Sándor FarkasdiGábor Varga
May 1, 2020·Metallomics : Integrated Biometal Science·M OmidiB J C Luthringer-Feyerabend
Feb 25, 2021·ACS Biomaterials Science & Engineering·Sutton E WheelisDanieli C Rodrigues
Apr 29, 2021·Biointerphases·Ahmet Engin PazarçevirenZafer Evis
Jun 10, 2021·Clinical Oral Implants Research·Atsushi KawamuraKatsumi Uoshima

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